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两名患者近期进行黑色纹身术后出现单发及多发角化棘皮瘤。

Single and multiple keratoacanthomas after a recent black tattoo in two patients.

作者信息

Al-Gawahiri Malak, van der Bent Sebastiaan A S, Clahsen Pieter, Vos Lydia E

机构信息

Dermatology, Haaglanden Medical Center, The Hague, The Netherlands.

Dermatology, Alrijne Hospital, Leiden, The Netherlands.

出版信息

BMJ Case Rep. 2024 Nov 21;17(11):e260760. doi: 10.1136/bcr-2024-260760.

DOI:10.1136/bcr-2024-260760
PMID:40242860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11590445/
Abstract

As studies on keratoacanthomas (KAs) within tattoos are scarce, our comprehension on the development of KAs in tattoos remains limited. Notably, existing studies predominantly focus on KAs found in tattoos containing red ink. This study addresses these gaps by documenting two cases of KAs within recently applied black and grey tattoos. The first case, a woman in her mid-40s, presented with two painful hyperkeratotic lesions in the tattooed skin on her left forearm and, notably, one similar simultaneously grown asymptomatic papule outside the tattooed skin. The second case, a man in his early 40s, presented with a painful hyperkeratotic nodule on a tattoo on the right leg. Histopathology showed that the nodules in both patients were compatible with a KA. After discussing therapeutic options, both patients opted for a wait-and-see approach, whereafter, the nodules regressed within months.

摘要

由于关于纹身内角化棘皮瘤(KA)的研究稀少,我们对纹身内KA发生发展的理解仍然有限。值得注意的是,现有研究主要集中在含红色墨水的纹身中发现的KA。本研究通过记录两例近期纹的黑白纹身内的KA来填补这些空白。第一例,一名45岁左右的女性,左前臂纹身皮肤出现两个疼痛性角化过度性皮损,值得注意的是,纹身皮肤外同时有一个类似的无症状丘疹也在生长。第二例,一名40岁出头的男性,右腿纹身处出现一个疼痛性角化过度性结节。组织病理学显示两名患者的结节均符合KA。在讨论了治疗方案后,两名患者都选择了观察等待,之后,结节在数月内消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc7/11590445/948befbe7b01/bcr-17-11-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc7/11590445/04334a52e3b2/bcr-17-11-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc7/11590445/27207258deab/bcr-17-11-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc7/11590445/948befbe7b01/bcr-17-11-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc7/11590445/04334a52e3b2/bcr-17-11-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc7/11590445/27207258deab/bcr-17-11-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfc7/11590445/948befbe7b01/bcr-17-11-g003.jpg

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本文引用的文献

1
Cutaneous Malignancies in Tattoos, a Case Series of Six Patients.纹身相关皮肤恶性肿瘤:六例病例系列
Curr Oncol. 2021 Nov 15;28(6):4721-4737. doi: 10.3390/curroncol28060398.
2
Complications of tattoos and permanent makeup: overview and analysis of 308 cases.纹身和永久性化妆的并发症:308 例概述与分析。
J Cosmet Dermatol. 2021 Nov;20(11):3630-3641. doi: 10.1111/jocd.14498. Epub 2021 Oct 3.
3
Analytical survey of tattoo inks-A chemical and legal perspective with focus on sensitizing substances.纹身油墨的分析调查——化学和法律视角,重点关注致敏物质。
Contact Dermatitis. 2021 Sep;85(3):340-353. doi: 10.1111/cod.13913. Epub 2021 Jun 22.
4
A clinical and biological review of keratoacanthoma.角化棘皮瘤的临床和生物学综述。
Br J Dermatol. 2021 Sep;185(3):487-498. doi: 10.1111/bjd.20389. Epub 2021 Jun 14.
5
Keratoacanthomas and Squamous Cell Carcinomas on Tattoos: A Review of 42 Cases.纹身部位的角化棘皮瘤和鳞状细胞癌:42例病例回顾
Dermatology. 2021;237(2):309-312. doi: 10.1159/000509728. Epub 2020 Sep 18.
6
Chemical composition and distribution of tattoo inks within tattoo-associated keratoacanthoma.纹身相关角化棘皮瘤内纹身墨水的化学成分及分布
J Eur Acad Dermatol Venereol. 2020 Jul;34(7):e313-e315. doi: 10.1111/jdv.16220. Epub 2020 Feb 16.
7
Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk.角化棘皮瘤的自发肿瘤消退是由Wnt/视黄酸信号串扰驱动的。
Nat Commun. 2014 Mar 26;5:3543. doi: 10.1038/ncomms4543.
8
Suggested excisional margins for cutaneous malignant lesions based on Mohs micrographic surgery.基于Mohs 显微外科的皮肤恶性病变建议切除边界。
JAMA Facial Plast Surg. 2013 Sep-Oct;15(5):337-43. doi: 10.1001/jamafacial.2013.1011.
9
The Bcl-xL inhibitor of apoptosis is preferentially expressed in cutaneous squamous cell carcinoma compared with that in keratoacanthoma.与角化棘皮瘤相比,凋亡抑制因子Bcl-xL在皮肤鳞状细胞癌中优先表达。
Int J Cancer. 2009 May 15;124(10):2361-6. doi: 10.1002/ijc.24197.