Zinneman H H, Caperton E
J Lab Clin Med. 1977 Mar;89(3):483-7.
The IgGK cryoglobulin in a patient with Sjögren's syndrome showed deviations from normal IgG involvine its amino acid composition as well as its carbohydrate components. The heavy chains showed abnormal numbers of arginine, threonine, valine and isoleucine residues, and there was an impressive reduction of fucose and hexose components. The carbohydrate deficits appear to be the reason for the incomplete solubility of the isolated IgGK(Ru) at 37 degrees C. with completion at 52 degrees C.
干燥综合征患者的IgGK冷球蛋白在氨基酸组成和碳水化合物成分方面均偏离正常IgG。重链的精氨酸、苏氨酸、缬氨酸和异亮氨酸残基数量异常，岩藻糖和己糖成分显著减少。碳水化合物缺乏似乎是分离出的IgGK(Ru)在37℃时不完全溶解而在52℃时完全溶解的原因。
