Djassemi Omeed, Saha Tamoghna, Nandhakumar Ponnusamy, Khan Muhammad Inam, Fishman Hannah, Earney Sara, Moonla Chochanon, Xu Yuchen, Thai Henry, Morales-Fermin Sofia, Kim Gyeongho, Park Rhea, Acot Beya, Wu Oscar, Wurster Cannon, Chang An-Yi, Cheung Christopher, Silberman Julia, Ding Shichao, Wang Joseph
Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Adv Sci (Weinh). 2025 Jul;12(26):e2502138. doi: 10.1002/advs.202502138. Epub 2025 Apr 17.
Accurate health analysis demands real-time tracking of multiple biomarkers and vital signs under dynamic physiological conditions. Current multimodal hybrid platforms provide biochemical and biophysical data but are limited by active sweat collection for biochemical sensing and bulky designs for biophysical sensing. Here a touch-enabled platform is presented that simultaneously monitors vitals and metabolic markers. With a simple tri-finger touch, the platform measures mean arterial pressure and heart rate using photoplethysmography, and glucose, uric acid, and cortisol at rest by leveraging the natural perspiration at the fingertip. Extended studies involving diverse activities reveal strong dynamic interplay among the metabolic and vital profiles, with mean arterial pressure showing the highest sensitivity to cortisol fluctuations. The platform delivers comprehensive health information linking diet, lifestyle, metabolism, and serves as an early metabolic or hormonal stress indicator. Valuable insights gained through the platform position it as a promising tool for personalized health and wellness management.
准确的健康分析需要在动态生理条件下实时跟踪多种生物标志物和生命体征。当前的多模态混合平台可提供生化和生物物理数据，但存在用于生化传感的主动汗液采集以及用于生物物理传感的笨重设计等局限性。在此展示了一个支持触摸的平台，该平台可同时监测生命体征和代谢标志物。通过简单的三指触摸，该平台利用光电容积脉搏波描记法测量平均动脉压和心率，并通过利用指尖的自然汗液测量静息状态下的葡萄糖、尿酸和皮质醇。涉及多种活动的扩展研究揭示了代谢和生命体征之间强烈的动态相互作用，其中平均动脉压对皮质醇波动的敏感性最高。该平台提供了将饮食、生活方式、新陈代谢联系起来的全面健康信息，并可作为早期代谢或激素应激指标。通过该平台获得的宝贵见解使其成为个性化健康和保健管理的有前途的工具。
