Singh Kanishk, Lin Chun-Chang, Huang Wei-Han, Lei Wan-Lou, Chiueh Herming, Wang Yu-Han, Chang Po-Hsueh, Lin Ru-Zheng, Huang Wei-Chen
Department of Electronics and Electrical Engineering, National Yang Ming Chiao Tung University1001 University Rd., Hsinchu City 30010, Taiwan.
The Affiliated Senior High School of National Taiwan Normal University, No. 143, Sec. 3, Xinyi Rd., Taipei City 106348, Taiwan.
ACS Appl Mater Interfaces. 2025 Apr 30;17(17):24887-24900. doi: 10.1021/acsami.4c23013. Epub 2025 Apr 17.
Continuous brain function monitoring by high-performance electroencephalogram (EEG) suggests a high impact for advancing precision personalized medication of neurodevelopmental or neurodegenerative disorders. Forehead and ear EEGs are nonhairy recording strategies that allow the recording of brain activity using only a few electrodes. However, they require well-designed electrodes that are easy and comfortable to carry while simultaneously performing durable high-quality EEG acquisition. Herein, we propose a new ultrabiocompliant EEG sensor that enables seamless contact to surfaces of both earhole and forehead, while permitting prolonged and high-quality EEG signal identification. Bioinspired polydopamine/platinum-silver nanowires, called PDA-Ag@Pt NWs, are synthesized with noticeable performances in electrical conductivity, antioxidation ability, cytocompatibility, and adhesion. PDA-Ag@Pt NWs can promote synchronic gelation and interlinks within polydopamine-polyacrylamide (PDA-PAM) hydrogels, in turn leading to the one-step formation of a nanowire/hydrogel matrix, called PDA-PAM/NW, as an electrode patch in the presence of adhesive and self-healing capabilities. Combined with a self-designed signal processor, a portable electrophysiological signal recording system was realized. The PDA-PAM/NW electrode patch outperformed commercial electrodes in terms of reliability and resolution for electrocardiography (ECG), electromyography (EMG), and electroencephalography (EEG) recording. In addition, through brain cognitive assessment by frontal- and ear-EEG recording, the ultrathin design and comfortable adhesion of PDA-PAM/NW electrodes make participants comfortable over time, subsequently providing the identification of the brain activity in high resolution. This work underscores the potential of the ultrabiocompliant and durable patch in the development of comfy, long-lasting, and high-performance wearable brain-machine interfaces for the revolution in neuroscience.
通过高性能脑电图（EEG）进行连续脑功能监测表明，这对推进神经发育或神经退行性疾病的精准个性化用药具有重大影响。前额和耳部脑电图是无需毛发处理的记录策略，仅使用少数电极就能记录大脑活动。然而，它们需要精心设计的电极，这种电极要易于携带且佩戴舒适，同时还要能持续进行高质量的脑电图采集。在此，我们提出一种新型的超生物相容性脑电图传感器，它能够与耳洞和前额表面实现无缝接触，同时可进行长时间的高质量脑电图信号识别。受生物启发合成的聚多巴胺/铂银纳米线，即PDA-Ag@Pt NWs，在导电性、抗氧化能力、细胞相容性和粘附性方面具有显著性能。PDA-Ag@Pt NWs可促进聚多巴胺-聚丙烯酰胺（PDA-PAM）水凝胶内的同步凝胶化和交联，进而在具有粘附和自愈能力的情况下一步形成纳米线/水凝胶基质（称为PDA-PAM/NW）作为电极贴片。结合自行设计的信号处理器，实现了一种便携式电生理信号记录系统。PDA-PAM/NW电极贴片在心电图（ECG）、肌电图（EMG）和脑电图（EEG）记录的可靠性和分辨率方面优于商业电极。此外，通过前额和耳部脑电图记录进行脑认知评估，PDA-PAM/NW电极的超薄设计和舒适粘附性使参与者长时间保持舒适，随后能够高分辨率识别大脑活动。这项工作凸显了这种超生物相容性和耐用贴片在开发舒适、持久且高性能的可穿戴脑机接口以推动神经科学革命方面的潜力。
