Heys R J, Heys D R, Cox C F, Avery J K
J Oral Pathol. 1977 Mar;6(2):63-81. doi: 10.1111/j.1600-0714.1977.tb01634.x.
Pulpal response of three bis glycol methacrylate composite resins, Smile, Simulate and Experimental Composite no. 2 were tested on primary and permanent monkey teeth using zinc oxide eugenol (ZOE) and silicate as controls. All materials were placed in Class V cavity preparations in Rhesus monkey teeth and evaluated at 3 days and 5 and 8 weeks. The materials were randomly placed in anterior and posterior teeth utilizing 75 primary and 75 permanent teeth. Following perfusion the teeth were prepared by routine histological procedures. The 3 day response of the composite resins was moderate, characterized by disruption of the odontoblasts, vacuolization and mild inflammatory response underlying the cavity. At 5 weeks the formation of reparative dentin and a decrease in the inflammatory response was similar for all resins observed. At 8 weeks a slight increase in reparative dentin and continued decrease in inflammation was noted when compared to the 5 weeks responses. At all time intervals ZOE produced the least pulpal response while silicate produced the most severe response.
使用氧化锌丁香酚（ZOE）和硅酸盐作为对照，在恒河猴的乳牙和恒牙上测试了三种双乙二醇甲基丙烯酸酯复合树脂（Smile、Simulate和实验性复合树脂2号）的牙髓反应。将所有材料置于恒河猴牙齿的V类窝洞中，并在3天以及5周和8周时进行评估。利用75颗乳牙和75颗恒牙，将材料随机放置在前牙和后牙中。灌注后，通过常规组织学程序制备牙齿。复合树脂在3天时的反应为中度，其特征为成牙本质细胞破坏、空泡化以及窝洞下方的轻度炎症反应。在5周时，所有观察到的树脂的修复性牙本质形成和炎症反应减轻情况相似。与5周时的反应相比，在8周时观察到修复性牙本质略有增加，炎症持续减轻。在所有时间间隔内，ZOE产生的牙髓反应最小，而硅酸盐产生的反应最严重。
