van den Berg Roland B, Stubbs Percival, Boumans-d'Onofrio Johanna R C, Swart Christina W, Steenstra Femke B, Oosterveld Paulien, Ng Shiwai, Klous Marjolein, Breukels Oscar, Kuijpers Eelco, Crul Mirjam
From the Department of Clinical Pharmacology and Pharmacy, Amsterdam UMC, location Vrije Universiteit, Amsterdam, the Netherlands (R.B.v.d.B., M.C.); Department of Hospital Pharmacy, Haaglanden Medisch Centrum, the Hague, the Netherlands (R.B.v.d.B.); Department of Human Resources, Health Team, Haaglanden Medisch Centrum, the Hague, the Netherlands (P.S.); Department of Human Resources, Occupational Health, Safety & Environmental Service, Radboudumc, Nijmegen, the Netherlands (J.R.C. B.-d'O.); Department of Clinical Pharmacy, University Medical Centre, Utrecht University, Utrecht, the Netherlands (C.W.S.); Occupational Health Department, University Medical Center Groningen, Groningen, the Netherlands (F.B.S.); Department of Human Resources, Leiden University Medical Center, Leiden, the Netherlands (P.O.); Laboratory of the Dutch Pharmacists, Royal Dutch Pharmacists Association, the Hague, the Netherlands (S.N.); Department of Pharmacy and Pharmacology, the Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands (M.K.); Department of Hospital Pharmacy, Meander Medical Center, Amersfoort, the Netherlands (O.B.); and Netherlands Organization for Applied Scientific Research, Utrecht, the Netherlands (E.K.).
J Occup Environ Med. 2025 Jul 1;67(7):571-579. doi: 10.1097/JOM.0000000000003401. Epub 2025 Apr 18.
This study evaluated healthcare workers' occupational exposure to inhaled drugs during drug reconstitution and handling tasks, focusing on compliance with occupational exposure limits (OELs).
Ten nurses and pharmacy technicians were monitored during an 8-hour shift to measure inhalable particle concentrations using a portable sampling device.
Inhalable particle concentrations ranged from <15 to 381 μg/m 3 (arithmetic mean 83 μg/m 3 ). Exposure to drugs in hazardous drug classes (HDCs) 1, 2, and 3 complied with OELs, while exposure to drugs in HDCs 4 and 5 exceeded OELs, highlighting the need for enhanced protective measures.
No additional precautions are needed for drugs in HDCs 1, 2, and 3, but dust exhaust or biosafety cabinets are recommended for handling drugs in HDCs 4 and 5.
本研究评估了医护人员在药物复溶和处理任务期间职业性吸入药物暴露情况，重点关注职业暴露限值（OELs）的合规性。
在8小时轮班期间对10名护士和药剂技术员进行监测，使用便携式采样设备测量可吸入颗粒物浓度。
可吸入颗粒物浓度范围为<15至381μg/m³（算术平均值83μg/m³）。对1、2和3类危险药物（HDCs）的药物暴露符合职业暴露限值，而对4和5类危险药物的药物暴露超过职业暴露限值，这突出表明需要加强防护措施。
对于1、2和3类危险药物无需采取额外预防措施，但建议在处理4和5类危险药物时使用排尘设备或生物安全柜。
