雷珠单抗注射后1型视网膜病变的黄斑光学相干断层扫描变化

OCT macular changes in type 1 ROP following Ranibizumab injections.

作者信息

Hosny Rawan, Gouda Jylan, Macky Tamer A, Khattab Ayman, Mekkawy Hany, Abdullatif Abdussalam M

机构信息

Department of Ophthalmology, Kasr AlAiny Hospital, Cairo University, 86 Saraya Street, Al Manial, Cairo, 11956, Egypt.

出版信息

Int J Retina Vitreous. 2025 Apr 17;11(1):47. doi: 10.1186/s40942-025-00664-7.

DOI:10.1186/s40942-025-00664-7

PMID:40247366

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12004622/

Abstract

AIM

To investigate the OCT macular changes in type 1 ROP one month following Ranibizumab injections.

METHODS

Preterm infants with type 1 ROP indicated for Ranibizumab injections were included in this study. Handheld OCT imaging was performed at baseline, 1 week, and 1 month post injection. Central full thickness (CFT), inner retinal layer (IRL), and outer retinal layer (ORL) thickness measurements were taken from foveal center and parafoveal region.

RESULTS

24 eyes of 12 infants were included in this study. There were no significant changes in the mean CFT and IRL thickness at 1 month (p = 0.5 and 0.1 respectively). However, there was significant increase in the mean ORL thickness at 1 month (69.9 ± 16, 96.1 ± 25 at baseline and one month respectively, p < 0.001), with differentiation (appearance of IS/OS junction ± ELM) in 55.6% of eyes. Macular edema (ME) was observed in 12 eyes (50%) and was associated with smaller birth weight (p = 0.0290). There was no significant decrease in mean CFT in eyes with ME at 1 month (p = 0.13), with complete resolution in only 6 eyes (50%) during the study period. Regression of plus was associated with lower CFT (1 week and 1 month; p = 0.02 and 0.03, respectively).

CONCLUSION

Ranibizumab treated eyes in type 1 show ORL thickening and differentiation but with inadequate resolution of ME.

摘要

目的

研究雷珠单抗注射1个月后1型视网膜病变（ROP）患者的黄斑区光学相干断层扫描（OCT）变化。

方法

本研究纳入了接受雷珠单抗注射的1型ROP早产儿。在基线、注射后1周和1个月进行手持式OCT成像。从黄斑中心和黄斑旁区域测量中央全层厚度（CFT）、视网膜内层（IRL）和视网膜外层（ORL）厚度。

结果

本研究纳入了12例婴儿的24只眼。1个月时平均CFT和IRL厚度无显著变化（p分别为0.5和0.1）。然而，1个月时平均ORL厚度显著增加（基线和1个月时分别为69.9±16、96.1±25，p<0.001），55.6%的眼出现了区分（IS/OS连接±ELM的出现）。12只眼（50%）观察到黄斑水肿（ME），且与出生体重较小有关（p=0.0290）。1个月时ME眼的平均CFT无显著降低（p=0.13），研究期间仅6只眼（50%）完全消退。ROP“加”征的消退与较低的CFT相关（1周和1个月时；p分别为0.02和0.03）。