Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Clin Perinatol. 2013 Jun;40(2):271-96. doi: 10.1016/j.clp.2013.02.007.
Retinopathy of Prematurity (ROP) is a leading cause of childhood blindness in the United States. Optical Coherence Tomography (OCT) is a relatively new imaging technology capable of imaging ocular structures in cross section at high resolution. We present an age-customized approach to perform Spectral Domain OCT in neonates and infants, and from SDOCT, the in-vivo development of the human fovea during the premature period up through term birth along with retinal changes unique to premature infants with ROP. Finally, we explore how this novel information may affect our understanding of ROP and the possible implications in vision and retinal development.
早产儿视网膜病变（ROP）是美国儿童失明的主要原因。光学相干断层扫描（OCT）是一种相对较新的成像技术，能够以高分辨率对眼部结构进行横截面成像。我们提出了一种年龄定制的方法，用于对新生儿和婴儿进行谱域 OCT 检查，并从 SDOCT 中可以看到，在早产儿时期，人类黄斑的发育过程一直持续到足月出生，以及早产儿 ROP 特有的视网膜变化。最后，我们探讨了这些新信息如何影响我们对 ROP 的理解以及对视力和视网膜发育的可能影响。
