Song Shi Long, Yu Wen Bing, Cai Xin Min, Ma Jie, Zou Lu Lu, Gao Li Li, Li Shi Ming
Department of Neurology, Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser Hospital), Qingdao, Shandong, China.
Teaching Center of Fundamental Courses, Ocean University of China, Qingdao, Shandong, China.
Front Aging Neurosci. 2025 Apr 3;17:1536515. doi: 10.3389/fnagi.2025.1536515. eCollection 2025.
Alzheimer's disease (AD) is the most common form of dementia globally, placing a substantial economic burden on patients and society. Exercise serves as an adjuvant therapy for AD with a low incidence of related adverse events. As a non-pharmacological intervention, it has demonstrated significant potential in the therapy of AD.
This study examines the key hotspots and emerging trends in exercise therapy for AD, offering valuable insights for researchers engaged in future research in this field.
The Web of Science Core Collection database was utilized to search for literature on exercise therapy for AD from January 1, 2000, to November 1, 2024, with 1,372 relevant articles being identified. And CiteSpace 6.2.R4 and VOSviewer were used to evaluate the bibliometric indicators.
Since 2000, the number of publications in the field of exercise therapy for AD has been increasing. In addition to the well-known areas of research, such as the impact of exercise on cognitive function, the combination of exercise and medication therapy, the effects of exercise on specific symptoms, and the exercise with music therapy, the field may also focus on more novel topics. These include the integration of the design and implementation of exercise interventions, exercise and dendritic spines, and exercise and neurophysiological mechanisms. Furthermore, an analysis of emerging keywords reveals that the current main research direction is exploring the specific physiological mechanisms through which exercise affects AD. This includes three emerging trends: the impact of exercise on cognitive impairment in AD patients, the effects of exercise on brain-derived neurotrophic factor (BDNF) and Amyloid beta, and the influence of exercise on Stress and neuroinflammation.
The research results indicate that interventions using exercise to alleviate the negative symptoms of AD, as well as combining exercise with medication for therapy, are gaining increasing attention from researchers. Meanwhile, novel topics such as exercise and music therapy, the design and implementation of exercise interventions, and neurophysiological mechanisms should also attract scholarly interest. Additionally, exploring the physiological mechanisms behind exercise therapy for AD could be a key focus for future research.
阿尔茨海默病（AD）是全球最常见的痴呆形式，给患者和社会带来了沉重的经济负担。运动作为AD的辅助治疗方法，相关不良事件发生率较低。作为一种非药物干预措施，它在AD治疗中显示出巨大潜力。
本研究探讨AD运动疗法的关键热点和新趋势，为该领域未来的研究人员提供有价值的见解。
利用科学网核心合集数据库检索2000年1月1日至2024年11月1日期间关于AD运动疗法的文献，共识别出1372篇相关文章。并使用CiteSpace 6.2.R4和VOSviewer评估文献计量指标。
自2000年以来，AD运动疗法领域的出版物数量一直在增加。除了运动对认知功能的影响、运动与药物治疗的结合、运动对特定症状的影响以及运动与音乐疗法等知名研究领域外，该领域可能还会关注更多新颖的主题。这些主题包括运动干预的设计与实施整合、运动与树突棘以及运动与神经生理机制。此外，对新兴关键词的分析表明，当前的主要研究方向是探索运动影响AD的具体生理机制。这包括三个新趋势：运动对AD患者认知障碍的影响、运动对脑源性神经营养因子（BDNF）和β淀粉样蛋白的影响，以及运动对压力和神经炎症的影响。
研究结果表明，利用运动缓解AD负面症状以及将运动与药物联合治疗的干预措施越来越受到研究人员的关注。同时，运动与音乐疗法、运动干预的设计与实施以及神经生理机制等新颖主题也应引起学术关注。此外，探索AD运动疗法背后的生理机制可能是未来研究的关键重点。
