Zhao Can, Qi Li-Hong, Li Long-Song, Wang Ying-Ying, Liang Ting, Chai Ning-Li
Chinese PLA Medical School, Beijing 100853, China.
Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
World J Gastroenterol. 2025 Apr 14;31(14):103921. doi: 10.3748/wjg.v31.i14.103921.
Current disinfection methods for gastrointestinal endoscopes consume a significant amount of water resources and produce a large volume of waste.
To achieve the objectives of efficiency, speed, and cost-effectiveness, this study utilized vaporized hydrogen peroxide (VHP) generated from sodium percarbonate granules to conduct an anhydrous disinfection test on gastrointestinal endoscopes.
The experimental device rapidly converts sodium percarbonate granules into VHP, and performs disinfection experiments on gastrointestinal endoscope models, disposable endoscopes, and various types of reusable gastrointestinal endoscopes. Variables such as the intraluminal flow rate (FR), relative humidity (RH), exposure dosage, and organic burden are used to explore the factors influencing the disinfection of long and narrow lumens with VHP.
The device generates a certain concentration of VHP that can achieve high-level disinfection of endoscope models within 30 minutes. RH, exposure dosage, and organic burden significantly affect the disinfection efficacy of VHP, whereas the intraluminal FR does not significantly impact disinfection efficacy. All ten artificially contaminated disposable endoscopes achieved satisfactory disinfection results. Furthermore, when this device was used to treat various types of reusable endoscopes, the disinfection and sterilization effects were not significantly different from those of automatic endoscope disinfection machines (using peracetic acid disinfectant solution) ( > 0.05), and the economic cost of disinfectant required per endoscope was lower (1.5 China Yuan), with a shorter disinfection time (30 minutes).
The methods and results of this study provide a basis for further research on the use of VHP for the disinfection of gastrointestinal endoscopes, as well as for the development of anhydrous disinfection technology for gastrointestinal endoscopes.
目前胃肠道内窥镜的消毒方法消耗大量水资源并产生大量废物。
为实现高效、快速和具有成本效益的目标，本研究利用过碳酸钠颗粒产生的汽化过氧化氢（VHP）对胃肠道内窥镜进行无水消毒试验。
实验装置将过碳酸钠颗粒快速转化为VHP，并对胃肠道内窥镜模型、一次性内窥镜和各种类型的可重复使用胃肠道内窥镜进行消毒实验。使用诸如管腔内流速（FR）、相对湿度（RH）、暴露剂量和有机负荷等变量来探索影响VHP对长而窄的管腔消毒的因素。
该装置产生一定浓度的VHP，可在30分钟内实现内窥镜模型的高水平消毒。RH、暴露剂量和有机负荷显著影响VHP的消毒效果，而管腔内FR对消毒效果无显著影响。所有十根人工污染的一次性内窥镜均取得了满意的消毒效果。此外，当使用该装置处理各种类型的可重复使用内窥镜时，消毒和灭菌效果与自动内窥镜消毒机（使用过氧乙酸消毒液）相比无显著差异（>0.05），且每根内窥镜所需消毒剂的经济成本较低（1.5元人民币），消毒时间较短（30分钟）。
本研究的方法和结果为进一步研究VHP用于胃肠道内窥镜消毒以及开发胃肠道内窥镜无水消毒技术提供了依据。
