Dyke-Davidoff-Masson syndrome is a rare neurologic condition wherein there is characteristic cerebral hemiatrophy that is either congenital or acquired, with a classical presentation of seizures, hemiparesis, and cognitive impairment. Here, we have an unusual case of a young, adult female who sustained a traumatic brain injury in her childhood leading to hemiatrophy but with minimal deficits. This study also summarizes the available data and discusses neuroplasticity and brain network connectivity.