Rathore Vedika, Gaikwad Kapila, Mahat Roshan K
Department of Biochemistry, Shyam Shah Medical College, Rewa, IND.
Department of Biochemistry, Dharanidhar Medical College and Hospital, Keonjhar, IND.
Cureus. 2025 Mar 18;17(3):e80785. doi: 10.7759/cureus.80785. eCollection 2025 Mar.
Introduction The triglyceride glucose (TyG) index and modified TyG-indices have been suggested as a reliable indication of insulin resistance. The present study aimed to investigate the predictive utility of TyG index and modified TyG indices (TyG-waist circumference, TyG-body mass index, TyG-waist-to-hip ratio, and TyG-waist-to-height ratio) for assessing glycemic control in type 2 diabetes mellitus (T2DM). Methods The present hospital-based cross-sectional study recruited 383 T2DM patients. On the basis of HbA1c levels, patients were grouped into poor glycemic control (n=168) and good glycemic control (n=215). Baseline and biochemical parameters including TyG and modified TyG indices were compared between the groups. We used a Spearman correlation analysis to look for an association between TyG and TyG-related indices and glycemic control. We conducted receiver operating characteristic curve analysis to evaluate the predictive capability of TyG-index and modified TyG indices in assessing poor glycemic control in T2DM. Results T2DM with poor glycemic control had significantly elevated TyG and modified TyG indices when compared to those with good glycemic control. The TyG index and modified TyG indices showed a strong correlation with glycemic control in individuals with T2DM. The TyG index exhibited greater predictive capacity for poor glycemic control as compared to the modified TyG indices. Conclusion Patients with T2DM who are treated in clinical settings with limited resources may benefit from using the TyG index to evaluate their glycemic control.
引言 甘油三酯葡萄糖（TyG）指数和改良的TyG指数已被认为是胰岛素抵抗的可靠指标。本研究旨在探讨TyG指数和改良的TyG指数（TyG-腰围、TyG-体重指数、TyG-腰臀比和TyG-腰高比）在评估2型糖尿病（T2DM）血糖控制方面的预测效用。方法 本基于医院的横断面研究招募了383例T2DM患者。根据糖化血红蛋白（HbA1c）水平，将患者分为血糖控制不佳组（n = 168）和血糖控制良好组（n = 215）。比较两组之间的基线和生化参数，包括TyG和改良的TyG指数。我们使用Spearman相关性分析来寻找TyG及与TyG相关的指数和血糖控制之间的关联。我们进行了受试者工作特征曲线分析，以评估TyG指数和改良的TyG指数在评估T2DM患者血糖控制不佳方面的预测能力。结果 与血糖控制良好的T2DM患者相比，血糖控制不佳的患者TyG和改良的TyG指数显著升高。TyG指数和改良的TyG指数与T2DM患者的血糖控制呈强相关性。与改良TyG指数相比，TyG指数对血糖控制不佳具有更大的预测能力。结论 在资源有限的临床环境中接受治疗的T2DM患者可能会受益于使用TyG指数来评估其血糖控制情况。
