Roifman C M, Lederman H M, Lavi S, Stein L D, Levison H, Gelfand E W
Am J Med. 1985 Aug;79(2):171-4. doi: 10.1016/0002-9343(85)90006-3.
Seven patients with hypogammaglobulinemia and chronic sinopulmonary infections were treated with a preparation of intravenous gammaglobulin. In order to maintain levels of serum IgG at greater than 500 to 750 mg/dl four weeks after infusion, 0.6 g/kg was administered every month. Stable serum levels were achieved after three to eight months. After six to 12 months of this regimen, there was significant reduction in acute infections requiring hospitalization, amelioration of clinical and radiographic evidence of chronic maxillary sinusitis, and improvement in pulmonary symptoms and pulmonary function test results. The administration of increased amounts of IgG intravenously is of benefit in patients with chronic sinopulmonary infections.
7例低丙种球蛋白血症合并慢性鼻窦肺部感染患者接受了静脉注射丙种球蛋白制剂治疗。为使输注后4周血清IgG水平维持在大于500至750mg/dl，每月给予0.6g/kg。3至8个月后达到稳定的血清水平。该治疗方案实施6至12个月后，需要住院治疗的急性感染显著减少，慢性上颌窦炎的临床和影像学证据得到改善，肺部症状及肺功能测试结果也有所改善。静脉注射增加剂量的IgG对慢性鼻窦肺部感染患者有益。
