1990年至2021年老年人腹泻病的全球负担及其可归因风险因素:来自《2021年全球疾病负担研究》的综合分析

Global burden of diarrhea disease in the older adult and its attributable risk factors from 1990 to 2021: a comprehensive analysis from the global burden of disease study 2021.

作者信息

Zhao Wen-Zhuo, Wang Jing-Yi, Zhang Min-Na, Wu Shang-Nong, Dai Wei-Jie, Yang Xiao-Zhong, Wang Hong-Gang

机构信息

Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.

出版信息

Front Public Health. 2025 Apr 4;13:1541492. doi: 10.3389/fpubh.2025.1541492. eCollection 2025.

Abstract

INTRODUCTION

Diarrhea disease among the older adult is an underappreciated global health issue despite its substantial burden. This study provides a comprehensive analysis of the epidemiological trends of diarrhea in individuals over 65 years, examining incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) from 1990 to 2021.

METHODS

Utilizing data from the Global Burden of Diseases (GBD) 2021, this cross-sectional study assesses the older adult population across 204 countries and territories. The analysis includes metrics such as incidence, prevalence, mortality, DALYs, and estimated annual percentage changes (EAPCs), stratified by region, country, age, sex, and Sociodemographic Index (SDI).

RESULTS

A nearly 200% increase in incidence and prevalence was observed worldwide, with the highest rise in those over 95 years. Mortality and DALYs have declined, especially in the 65-69 age group. High SDI regions showed the largest increase in incidence rates and are the only areas with increasing mortality and DALYs trends. Unsafe water sources emerged as the primary risk factor for diarrhea-related deaths among the older adult.

DISCUSSION

The burden of diarrhea in the older adult has significantly increased, particularly in high-income regions, warranting targeted interventions. The positive correlation between EAPC and the Human Development Index underscores the need for improved water safety to mitigate the disease burden. This study's findings are crucial for shaping public health strategies and informing policy decisions regarding the older adult population.

摘要

引言

尽管老年人群腹泻病负担沉重,但这一全球健康问题仍未得到充分重视。本研究全面分析了65岁以上人群腹泻的流行病学趋势,考察了1990年至2021年期间的发病率、患病率、死亡率及伤残调整生命年(DALYs)。

方法

利用全球疾病负担(GBD)2021的数据,这项横断面研究评估了204个国家和地区的老年人口。分析指标包括发病率、患病率、死亡率、DALYs以及估计年变化百分比(EAPCs),并按地区、国家、年龄、性别和社会人口指数(SDI)进行分层。

结果

全球范围内发病率和患病率增长近200%,95岁以上人群增长幅度最大。死亡率和DALYs有所下降,尤其是在65 - 69岁年龄组。高SDI地区发病率增长幅度最大,且是死亡率和DALYs呈上升趋势的唯一地区。不安全水源成为老年人群腹泻相关死亡的主要风险因素。

讨论

老年人群腹泻负担显著增加,尤其是在高收入地区,需要有针对性的干预措施。EAPC与人类发展指数之间的正相关关系凸显了改善水安全以减轻疾病负担必要性。本研究结果对于制定公共卫生策略以及为老年人群相关政策决策提供信息至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e9f/12006145/1e0a86ad8b64/fpubh-13-1541492-g0001.jpg

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