Abbas Mohamed Ali Mahmoud, Elgamal Emad Eldin Abd Elmoneim, Zaky Mohamed Shokry, Elsaie Mohamed L
Department of Medical Physiology, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Department of Dermatology, Venereology and Andrology, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Dermatol Ther. 2022 May;35(5):e15376. doi: 10.1111/dth.15376. Epub 2022 Feb 21.
Post acne scars following sebaceous injury and abnormal wound healing during the course of acne is a prevalent and challenging to treat condition To evaluate microneedling by dermapen with topical vitamin C versus microneedling with topical insulin in treating atrophic post-acne scars. A split-face comparative study included 30 subjects with atrophic post-acne scars. Human insulin was topically applied to the left side of the face and on the right side, vitamin C serum was applied. Scars were assessed via the Acne Scar Assessment Scale (ASAS) and Scar quartile grading scale (SQGS). After 1 month of 4 treatments, a statistically significant mean improvement in ASAS value was reported on both split sides of the face (2.13 and 1.83) compared to baseline (3.03 and 2.93) (p = 0.005; p = 0.001 respectively). When compared to baseline, the mean ASAS value improved significantly with a slight more improvement on the vitamin c treated side. Topical insulin and vitamin c combined with microneedling, may both achieve comparable significant improvement for treating post acne scars. Insulin can be a promising novel anti-scarring therapy pending larger controlled studies to verify its efficacy.
痤疮病程中皮脂腺损伤及异常伤口愈合后形成的痤疮后瘢痕是一种常见且治疗具有挑战性的病症。为评估使用含局部维生素C的电动微针与使用局部胰岛素的电动微针治疗萎缩性痤疮后瘢痕的效果。一项半脸对照研究纳入了30名患有萎缩性痤疮后瘢痕的受试者。将人胰岛素局部涂抹于面部左侧，右侧涂抹维生素C血清。通过痤疮瘢痕评估量表（ASAS）和瘢痕四分位数分级量表（SQGS）对瘢痕进行评估。在进行4次治疗1个月后，与基线值（3.03和2.93）相比，面部两侧（分别为2.13和1.83）的ASAS值均有统计学意义的显著改善（p = 0.005；p = 0.001）。与基线相比，平均ASAS值显著改善，且维生素C治疗侧改善稍多。局部胰岛素和维生素C联合微针治疗在治疗痤疮后瘢痕方面均可取得相当显著的改善。在有更多对照研究验证其疗效之前，胰岛素可能是一种有前景的新型抗瘢痕治疗方法。
