Celayir Arın, Marangoz Hasan, Göktürk Özcan Gamze, Abdullaev Nuraddin, Camurdan Vedat Burkay, Karaismailoglu Bedri
Department of Orthopedics and Traumatology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, TUR.
Department of Pathology, Henry Ford Hospital, Detroit, USA.
Cureus. 2025 Mar 20;17(3):e80918. doi: 10.7759/cureus.80918. eCollection 2025 Mar.
Giant cell tumor of the tendon sheath (GCT-TS) is a benign yet locally aggressive soft tissue neoplasm that typically arises in synovium-lined structures, including tendon sheaths, bursae, and joints. Also known as localized nodular tenosynovitis, this tumor primarily affects the hands and fingers but can occur in other anatomical locations. GCT-TS is histologically characterized by multinucleated giant cells within a background of mononuclear stromal cells. While it is generally nonmetastatic, the tumor carries a risk of local recurrence following surgical removal. Recognizing the clinical presentation, histopathological features, and appropriate management strategies is essential for effective treatment and recurrence prevention. Here, we present the case of a 34-year-old woman with a one-year history of pain in the infrapatellar region. Imaging revealed a well-defined soft tissue mass posterior to the patellar tendon, which was surgically excised. Histopathological examination confirmed the diagnosis of nodular-type GCT-TS. The patient's symptoms resolved completely postoperatively, and no recurrence was observed during a five-year follow-up period, highlighting the effectiveness of surgical excision in managing this rare tumor location.
腱鞘巨细胞瘤（GCT-TS）是一种良性但具有局部侵袭性的软组织肿瘤，通常发生于滑膜衬里结构，包括腱鞘、滑囊和关节。这种肿瘤也被称为局限性结节性腱鞘炎，主要累及手部和手指，但也可发生于其他解剖部位。GCT-TS的组织学特征是在单核基质细胞背景中存在多核巨细胞。虽然它一般不发生转移，但手术切除后该肿瘤有局部复发的风险。认识其临床表现、组织病理学特征及合适的治疗策略对于有效治疗和预防复发至关重要。在此，我们报告一例34岁女性，其髌下区域疼痛病史1年。影像学检查显示髌腱后方有一个边界清晰的软组织肿块，遂行手术切除。组织病理学检查确诊为结节型GCT-TS。患者术后症状完全缓解，在5年随访期内未观察到复发，突出了手术切除在处理这一罕见肿瘤部位时的有效性。
