Ou Xue, Yu Zhijie, Pan Chuanyu, Zheng Xi, Li Dandan, Qiao Zhenzhen, Zheng Xiaoyuan
Pharmacy Department, Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China.
Front Pharmacol. 2025 Apr 7;16:1551368. doi: 10.3389/fphar.2025.1551368. eCollection 2025.
The escalating global prevalence of diabetes underscores the urgency of addressing its treatment and associated complications. Paeoniflorin, a monoterpenoid glycoside compound, has garnered substantial attention in recent years owing to its potential therapeutic efficacy in diabetes management. Thus, this study aims to systematically overview the pharmacological effects, pharmacokinetics and toxicity of paeoniflorin in diabetes. Plenty of evidences have verified that paeoniflorin improves diabetes and its complication through reducing blood sugar, enhancing insulin sensitivity, regulating gut microbiota and autophagy, restoration of mitochondrial function, regulation of lipid metabolism, anti-inflammation, anti-oxidative stress, inhibition of apoptosis, immune regulation and so on. Paeoniflorin possess the characteristics of rapid absorption, wide distribution, rapid metabolism and renal excretion. Meanwhile, toxicity studies have suggested that paeoniflorin has low acute toxicity, minimal subacute and chronic toxicity, and no genotoxic or mutational toxic effects. In conclusion, this paper systematically elucidates the potential therapeutic application and safety profile of paeoniflorin in diabetes management.
全球糖尿病患病率不断攀升，凸显了应对其治疗及相关并发症的紧迫性。芍药苷是一种单萜糖苷化合物，近年来因其在糖尿病管理中的潜在治疗功效而备受关注。因此，本研究旨在系统综述芍药苷在糖尿病中的药理作用、药代动力学和毒性。大量证据证实，芍药苷可通过降低血糖、增强胰岛素敏感性、调节肠道微生物群和自噬、恢复线粒体功能、调节脂质代谢、抗炎、抗氧化应激、抑制细胞凋亡、免疫调节等改善糖尿病及其并发症。芍药苷具有吸收迅速、分布广泛、代谢快和经肾排泄的特点。同时，毒性研究表明，芍药苷急性毒性低，亚急性和慢性毒性极小，且无遗传毒性或致突变毒性作用。总之，本文系统阐明了芍药苷在糖尿病管理中的潜在治疗应用和安全性。
