Esin Burcu, Kaya Cumali, Esin Çağatay
Department of Animal Reproduction and Artificial Insemination, University of Ondokuz Mayis, Samsun, Turkey.
Department of Veterinary Internal Medicine, Faculty of Veterinary Medicine, University of Ondokuz Mayis, Samsun, Turkey.
Vet Med Sci. 2025 May;11(3):e70337. doi: 10.1002/vms3.70337.
Benign prostatic hyperplasia (BPH) is a prevalent condition affecting the prostate gland in adult male dogs, often resulting in significant clinical manifestations. Doppler ultrasonography offers a non-invasive method to assess prostatic haemodynamics and vascular properties, which are crucial for understanding the pathophysiology of BPH and treatment effects.
This study aimed to evaluate the effects of finasteride treatment on the haemodynamic and vascular properties of the canine prostate using B-mode and Doppler ultrasonography.
Sixteen dogs of different breeds, body weights (20-43 kg) and ages (6-13 years) were used in the study and classified into a healthy control group (n = 8) and a BPH group (n = 8). BPH presumptive diagnosis was performed through reproductive history, clinical signs (tenesmus, haematuria or dysuria) and prostatic volume by B-mode ultrasonography. The BPH group received finasteride treatment for 2 months. Prostate volume (PV), peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index (RI) and pulsatility index (PI) were measured before and after treatment using B-mode and Doppler ultrasonography.
The BPH group exhibited a significant reduction in PV from 25.10 ± 18.55 cm to 18.55 ± 4.18 cm post-treatment (p < 0.05). PSV and EDV were significantly higher in the BPH group (p < 0.001) than in the healthy control group (p < 0.05). The BPH pre-treatment group had higher RI and PI values than the post-treatment group (p < 0.05). Additionally, finasteride treatment led to a marked decrease in RI and PI values (p < 0.05), bringing these parameters in line with those of healthy dogs. Enhanced blood flow parameters were observed, indicating the effectiveness of finasteride in reducing prostatic vascular resistance and improving overall prostate health.
Finasteride treatment is effective in reducing PV and improving blood flow parameters in dogs with BPH. Doppler ultrasonography is a valuable tool for monitoring treatment response and assessing prostatic haemodynamics in canine BPH.
良性前列腺增生（BPH）是成年雄性犬前列腺常见的病症，常导致明显的临床表现。多普勒超声检查提供了一种非侵入性方法来评估前列腺血流动力学和血管特性，这对于理解BPH的病理生理学和治疗效果至关重要。
本研究旨在使用B型和多普勒超声检查评估非那雄胺治疗对犬前列腺血流动力学和血管特性的影响。
本研究使用了16只不同品种、体重（20 - 43千克）和年龄（6 - 13岁）的犬，分为健康对照组（n = 8）和BPH组（n = 8）。通过繁殖史、临床症状（里急后重、血尿或排尿困难）以及B型超声检查的前列腺体积进行BPH的初步诊断。BPH组接受非那雄胺治疗2个月。使用B型和多普勒超声检查在治疗前后测量前列腺体积（PV）、收缩期峰值流速（PSV）、舒张末期流速（EDV）、阻力指数（RI）和搏动指数（PI）。
BPH组治疗后PV从25.10 ± 18.55立方厘米显著降至18.55 ± 4.18立方厘米（p < 0.05）。BPH组的PSV和EDV显著高于健康对照组（p < 0.001）（p < 0.05）。BPH治疗前组的RI和PI值高于治疗后组（p < 0.05）。此外，非那雄胺治疗导致RI和PI值显著降低（p < 0.05），使这些参数与健康犬的参数一致。观察到血流参数增强，表明非那雄胺在降低前列腺血管阻力和改善整体前列腺健康方面有效。
非那雄胺治疗对降低BPH犬的PV和改善血流参数有效。多普勒超声检查是监测治疗反应和评估犬BPH前列腺血流动力学的有价值工具。
