Cunnane S C, Manku M S, Horrobin D F
Ann Nutr Metab. 1985;29(4):246-52. doi: 10.1159/000176977.
In choice situations, the golden Syrian hamster shows a strong preference to drink an ethanol solution to water alone. Because of the known effects of ethanol on lipid metabolism, its effects on liver fatty acids were therefore studied in the hamster. After a period of 8 weeks during which hamsters had consumed water containing 10% ethanol (4 weeks) and then 15% ethanol (4 weeks), the liver was significantly increased in weight, an effect which was shown to be due to fat accumulation as triglyceride. The fatty acid composition of the liver triglycerides and phospholipids was altered such that monounsaturated fatty acids were very significantly increased and both n-6 and n-3 essential fatty acids were proportionally decreased.
在选择实验中，金黄地鼠表现出强烈偏好饮用乙醇溶液而非单纯的水。鉴于乙醇对脂质代谢的已知影响，因此研究了其对仓鼠肝脏脂肪酸的影响。在仓鼠饮用含10%乙醇的水4周，然后饮用含15%乙醇的水4周的8周期间后，肝脏重量显著增加，结果表明这种增加是由于甘油三酯形式的脂肪积累所致。肝脏甘油三酯和磷脂的脂肪酸组成发生了改变，使得单不饱和脂肪酸显著增加，而n-6和n-3必需脂肪酸均成比例下降。
