Harris R A, Krause W, Goh E, Case J
Pharmacol Biochem Behav. 1979 Mar;10(3):343-7. doi: 10.1016/0091-3057(79)90195-3.
Male Syrian Golden-Hamsters consumed about 90% of their fluid as an ethanol-water solution when given a choice between water and ethanol-water solutions. This resulted in a daily alcohol intake of about 11 g/kg. After 53 days of alcohol ingestion there was no evidence of tolerance to the soporific effects of parenterally administered ethanol and removal of the ethanol solutions failed to produce any signs of alcohol withdrawal. However, after cessation of ethanol ingestion, the acquisition of escape responding from footshock was impaired in the alcohol group as compared to a control group. Biochemical and ultrastructural analyses demonstrated that chronic ethanol ingestion hepatic glycogen and plasma triglycerides without altering either the hepatic or plasma concentrations of phospholipids, free cholesterol or cholesterol esters. These results demonstrate that the hamster has an unusual metabolic response to ethanol. These findings are contrasted to the biochemical and behavioral effects of the drug in other species.
当在水和乙醇 - 水溶液之间进行选择时，雄性叙利亚金黄地鼠所摄入的液体约90%为乙醇 - 水溶液。这导致每日酒精摄入量约为11克/千克。在摄入酒精53天后，没有证据表明对肠胃外给予乙醇的催眠作用产生耐受性，且去除乙醇溶液也未产生任何酒精戒断迹象。然而，在停止摄入乙醇后，与对照组相比，酒精组从足部电击逃脱反应的习得受到损害。生化和超微结构分析表明，长期摄入乙醇会使肝糖原和血浆甘油三酯增加，而不会改变肝或血浆中磷脂、游离胆固醇或胆固醇酯的浓度。这些结果表明，地鼠对乙醇有不同寻常的代谢反应。这些发现与该药物在其他物种中的生化和行为效应形成对比。
