Luna-Rojas Sofía L, Vázquez-Guerrero Edwin, Hernández-Martínez Jose A, Serafín-López Jeanet, Martínez-Hernández Fernando, Martinez-Ibarra José Alejandro, Hernández-Castro Rigoberto, López Job E, Ibarra J Antonio
Laboratorio de Genética Microbiana, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
Am J Trop Med Hyg. 2025 Apr 22;113(1):117-119. doi: 10.4269/ajtmh.24-0636. Print 2025 Jul 2.
Relapsing fever caused by Borrelia sp. is a neglected disease in Mexico and more studies are needed to update its presence in multiple regions of the country. Here, recombinant proteins glycerophosphodiester phosphodiesterase (GlpQ) and three Borrelia immunogenic protein A (BipA) variants were used for serosurveillance in 142 human serum samples. Results showed that two persons were positive to Borrelia extracts and GlpQ but negative to all three BipA, suggesting they were infected by relapsing fever spirochetes of a yet to be determined species. This shows that testing for GlpQ and Borrelia extracts are a useful tool for potential infections and grants their use in other regions and studies in Mexico.
由疏螺旋体属引起的回归热在墨西哥是一种被忽视的疾病，需要开展更多研究以了解其在该国多个地区的情况。在此，利用重组蛋白甘油磷酸二酯磷酸二酯酶（GlpQ）和三种疏螺旋体免疫原性蛋白A（BipA）变体对142份人血清样本进行了血清学监测。结果显示，两人对疏螺旋体提取物和GlpQ呈阳性反应，但对所有三种BipA均呈阴性反应，这表明他们感染了一种尚未确定的回归热螺旋体。这表明，检测GlpQ和疏螺旋体提取物是检测潜在感染的有用工具，并允许在墨西哥的其他地区和研究中使用。
