Sutton A M, Harvie A, Cockburn F, Farquharson J, Logan R W
Arch Dis Child. 1985 Jul;60(7):644-51. doi: 10.1136/adc.60.7.644.
Four preterm infants of very low birthweight (less than 1500 g) developed signs of copper deficiency between age 8 and 10 weeks. All had required prolonged ventilatory support, parenteral nutrition, and nasojejunal feeding. The clinical features, which included osteoporosis, oedema, anaemia, neutropenia, and late apnoea improved when the oral copper intake was increased. Diagnosis was made more difficult because a suitable reference range for plasma copper was not available. Serial measurements of plasma copper in 39 preterm infants who had no important medical problems were used to produce a reference range for plasma copper from 30 weeks' gestation to term plus seven weeks. This information will aid recognition of hypocupraemia in the very low birthweight infant who is particularly at risk of copper deficiency.
4名极低出生体重（低于1500克）的早产儿在8至10周龄时出现铜缺乏的体征。所有患儿均需要长时间的通气支持、肠外营养和鼻空肠喂养。当口服铜摄入量增加时，包括骨质疏松、水肿、贫血、中性粒细胞减少和晚期呼吸暂停在内的临床症状有所改善。由于没有合适的血浆铜参考范围，诊断变得更加困难。对39名无重大医疗问题的早产儿进行血浆铜的系列测量，以得出从妊娠30周到期满加7周的血浆铜参考范围。这些信息将有助于识别极低出生体重、尤其有铜缺乏风险的婴儿的低铜血症。
