伴有IgG2缺乏的复发性感染
Recurrent infections with IgG2 deficiency.
作者信息
Plebani A, Duse M, Monafo V
出版信息
Arch Dis Child. 1985 Jul;60(7):670-2. doi: 10.1136/adc.60.7.670.
Abstract
An 11 year old girl with retarded growth, recurrent infections, bronchiectasis, and normal serum immunoglobulin concentrations had a combined deficit of the IgG2 subclass and IgG and IgM specific antibodies. Immunoglobulin replacement was followed by clinical improvement. The importance of determining both IgG subclasses and antibody activity in patients with recurrent infections and normal serum immunoglobulin values is emphasised.
摘要
一名11岁女孩生长发育迟缓、反复感染、患有支气管扩张症，血清免疫球蛋白浓度正常，但存在IgG2亚类以及IgG和IgM特异性抗体的联合缺陷。进行免疫球蛋白替代治疗后临床症状改善。强调了对于反复感染且血清免疫球蛋白值正常的患者，测定IgG亚类和抗体活性的重要性。
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Recurrent meningococcemia associated with IgG2-subclass deficiency.
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IgG1 is the predominant subclass of in vivo- and in vitro- produced anti-tetanus toxoid antibodies and also serves as the membrane IgG molecule for delivering inhibitory signals to anti-tetanus toxoid antibody-producing B cells.IgG1是体内和体外产生的抗破伤风类毒素抗体的主要亚类，并且还作为膜IgG分子，用于向产生抗破伤风类毒素抗体的B细胞传递抑制信号。
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Clin Exp Immunol. 1968 Jan;3(1):47-56.
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Activity of the alternative complement pathway after splenectomy: comparison to activity in sickle cell disease and hypogammaglobulinemia.脾切除术后替代补体途径的活性：与镰状细胞病和低丙种球蛋白血症患者活性的比较。
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