Gillard G C, Lowther D A
Arthritis Rheum. 1976 Sep-Oct;19(5):918-22. doi: 10.1002/art.1780190513.
An inflammation of the periarticular tissue induced by the intraarticular injection of carrageenin caused a 40-75% decrease in the rate of proteoglycan synthesis in the articular cartilage. This decrease was determined both in vitro and in vivo. Provided that the collagen network of the cartilage was not disrupted, the chondrocytes were able to recover this synthetic ability and exhibited rates of synthesis above those of the controls. This ability resulted in a net replacement of the proteoglycan lost during the initial period of inflammation.
关节内注射角叉菜胶引起的关节周围组织炎症，导致关节软骨中蛋白聚糖合成速率降低40%-75%。这种降低在体外和体内均得到测定。倘若软骨的胶原网络未被破坏，软骨细胞能够恢复这种合成能力，且合成速率高于对照组。这种能力导致在炎症初期丢失的蛋白聚糖得到净补充。
