Carmichael D J, Gillard G C, Lowther D A, Handley C J, Santer V B
Arthritis Rheum. 1977 Apr;20(3):834-40. doi: 10.1002/art.1780200313.
A localized inflammatory response was initiated by both single and repeated injections of carrageenin into femorotibial joints. Histologic changes were observed 24 hours after a single intraarticular injection, and an inhibition in the in vitro rate of proteoglycan synthesis was detected 72 hours after the injection. This inhibition was relieved in vitro by the addition of beta-D-xyloside, an exogenous initiator of glycosaminoglycan biosynthesis. Following repeated carrageenin injections, most cells appeared to be dead on histologic examination and no in vitro proteoglycan synthesis could be detected; nor could any stimulation be achieved by adding exyloside.
通过向股胫关节单次和重复注射角叉菜胶引发局部炎症反应。单次关节内注射后24小时观察到组织学变化，注射后72小时检测到蛋白聚糖合成的体外速率受到抑制。通过添加β-D-木糖苷（一种糖胺聚糖生物合成的外源性引发剂），这种抑制在体外得到缓解。重复注射角叉菜胶后，组织学检查显示大多数细胞似乎已死亡，未检测到体外蛋白聚糖合成；添加木糖苷也无法实现任何刺激。
