Du Bowei, Feng Shuhan, Wang Jiajun, Cao Keyi, Shi Zhiheng, Men Cuicui, Yu Tengfei, Wang Shiqi, Huang Yaqin
Beijing Laboratory of Biomedical Materials, Key Laboratory of Biomedical Materials of Natural Macromolecules, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland.
Chin Med J (Engl). 2025 May 20;138(10):1135-1152. doi: 10.1097/CM9.0000000000003611. Epub 2025 Apr 22.
Collagen-based materials, renowned for their biocompatibility and minimal immunogenicity, serve as exemplary substrates in a myriad of biomedical applications. Collagen-based micro/nanogels, in particular, are valued for their increased surface area, tunable degradation rates, and ability to facilitate targeted drug delivery, making them instrumental in advanced therapeutics and tissue engineering endeavors. Although extensive reviews on micro/nanogels exist, they tend to cover a wide range of biomaterials and lack a specific focus on collagen-based materials. The current review offers an in-depth look into the manufacturing technologies, drug release mechanisms, and biomedical applications of collagen-based micro/nanogels to address this gap. First, we provide an overview of the synthetic strategies that allow the precise control of the size, shape, and mechanical strength of these collagen-based micro/nanogels by controlling the degree of cross-linking of the materials. These properties are crucial for their performance in biomedical applications. We then highlight the environmental responsiveness of these collagen-based micro/nanogels, particularly their sensitivity to enzymes and pH, which enables controlled drug release under various pathological conditions. The discussion then expands to include their applications in cancer therapy, antimicrobial treatments, bone tissue repair, and imaging diagnosis, emphasizing their versatility and potential in these critical areas. The challenges and future perspectives of collagen-based micro/nanogels in the field are discussed at the end of the review, with an emphasis on the translation to clinical practice. This comprehensive review serves as a valuable resource for researchers, clinicians, and scientists alike, providing insights into the current state and future directions of collagen-based micro/nanogel research and development.
基于胶原蛋白的材料以其生物相容性和低免疫原性而闻名，在众多生物医学应用中作为典范性的基质。特别是基于胶原蛋白的微/纳米凝胶，因其增加的表面积、可调节的降解速率以及促进靶向药物递送的能力而受到重视，使其在先进治疗和组织工程领域发挥重要作用。尽管存在关于微/纳米凝胶的广泛综述，但它们往往涵盖了广泛的生物材料，缺乏对基于胶原蛋白材料的特定关注。本综述深入探讨基于胶原蛋白的微/纳米凝胶的制造技术、药物释放机制和生物医学应用，以填补这一空白。首先，我们概述了合成策略，通过控制材料的交联程度来精确控制这些基于胶原蛋白的微/纳米凝胶的尺寸、形状和机械强度。这些特性对它们在生物医学应用中的性能至关重要。然后，我们强调这些基于胶原蛋白的微/纳米凝胶的环境响应性，特别是它们对酶和pH的敏感性，这使得在各种病理条件下能够实现可控的药物释放。随后的讨论扩展到包括它们在癌症治疗、抗菌治疗、骨组织修复和成像诊断中的应用，强调它们在这些关键领域的多功能性和潜力。综述结尾讨论了基于胶原蛋白的微/纳米凝胶在该领域面临的挑战和未来前景，重点是向临床实践的转化。这一全面综述为研究人员、临床医生和科学家等提供了宝贵资源，深入了解基于胶原蛋白的微/纳米凝胶研究与开发的现状和未来方向。
