Pareek Anil, Kumar Sanjesh, Kapoor Devesh U, Prajapati Bhupendra G
Department of Pharmaceutics, Lachoo Memorial College of Science and Technology (Autonomous), Jodhpur, Rajasthan 342003, India.
Rakshpal Bahadur College of Pharmacy Bareilly, 243001 Uttar Pradesh, India.
Int J Pharm. 2025 May 30;677:125683. doi: 10.1016/j.ijpharm.2025.125683. Epub 2025 May 5.
Superparamagnetic nanogels represent a groundbreaking advancement in nanotechnology, combining the unique properties of superparamagnetic materials with the versatility of nanogels to create multifunctional platforms for biomedical applications. These innovative constructs play a dual role in diagnosis and targeted drug delivery, addressing critical challenges in modern healthcare. This review paper explores the synthesis, characterization, and applications of superparamagnetic nanogels, providing a comprehensive overview of their potential impact in biomedicine. The synthesis section outlines various materials, fabrication techniques, and surface functionalization methods used to enhance their functionality and biocompatibility. Characterization techniques are discussed, focusing on their structural, magnetic, and biological properties. In diagnostic applications, superparamagnetic nanogels excel as contrast agents for magnetic resonance imaging, biosensors, and tools for real-time disease monitoring. Their superior sensitivity and specificity offer unprecedented opportunities for early disease detection and personalized treatment. In drug delivery, these nanogels demonstrate remarkable efficiency in encapsulating therapeutic agents and enabling controlled release. Magnetic guidance enhances targeting precision, minimizing off-target effects and improving therapeutic outcomes, particularly in cancer therapy. The dual-role capability of these nanogels underscores their potential as transformative tools in precision medicine. This review emphasizes recent advancements, highlighting the challenges and future perspectives in optimizing superparamagnetic nanogels for clinical translation. By bridging the gap between innovative design and practical application, this work aims to inspire further research and development in this dynamic field.
超顺磁性纳米凝胶代表了纳米技术的一项突破性进展，它将超顺磁性材料的独特性质与纳米凝胶的多功能性相结合，为生物医学应用创建多功能平台。这些创新结构在诊断和靶向药物递送中发挥双重作用，解决了现代医疗保健中的关键挑战。这篇综述文章探讨了超顺磁性纳米凝胶的合成、表征及应用，全面概述了它们在生物医学中的潜在影响。合成部分概述了用于增强其功能和生物相容性的各种材料、制备技术及表面功能化方法。讨论了表征技术，重点关注其结构、磁性和生物学性质。在诊断应用中，超顺磁性纳米凝胶作为磁共振成像的造影剂、生物传感器及实时疾病监测工具表现出色。它们卓越的灵敏度和特异性为疾病早期检测和个性化治疗提供了前所未有的机会。在药物递送方面，这些纳米凝胶在包封治疗剂和实现控释方面表现出显著效率。磁导向提高了靶向精度，最大限度地减少脱靶效应并改善治疗效果，尤其是在癌症治疗中。这些纳米凝胶的双重作用能力突显了它们作为精准医学中变革性工具的潜力。本综述强调了近期的进展，突出了优化超顺磁性纳米凝胶用于临床转化所面临的挑战和未来前景。通过弥合创新设计与实际应用之间的差距，这项工作旨在激发该动态领域的进一步研究与开发。
