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工程化杯状纳米马达用于促进细胞内化及协同肿瘤治疗

Engineering Cup-Shaped Nanomotors for Promoting Cell Internalization and Synergistic Tumor Therapy.

作者信息

Feng Ning, Liang Longteng, Liu Yufang

机构信息

Henan Key Laboratory of Infrared Materials & Spectrum Measures and Applications, School of Physics, Henan Normal University, Xinxiang 453007, China.

Institute of Physics, Henan Academy of Sciences, Zhengzhou 450046, China.

出版信息

Research (Wash D C). 2025 Apr 22;8:0623. doi: 10.34133/research.0623. eCollection 2025.

Abstract

Self-propulsion enzymatic nanomotors have shown tremendous potential in the field of diagnostics. In a study led by Wang and coworkers, nanoenzyme-driven cup-shaped nanomotors were designed for enhanced cell penetration and synergistic photodynamic/thermal treatments under single near-infrared laser irradiation. By combining the concepts of self-propulsion enzymatic nanomotors and synergistic dual-modal therapy, this work provides a new idea and tool for the application of nanomotors in the biomedical field.

摘要

自驱动酶纳米马达在诊断领域已展现出巨大潜力。在王及其同事领导的一项研究中,设计了纳米酶驱动的杯状纳米马达,用于在单一近红外激光照射下增强细胞穿透及协同光动力/热疗。通过结合自驱动酶纳米马达与协同双模态治疗的概念,这项工作为纳米马达在生物医学领域的应用提供了新思路和工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d8d/12012295/0cecdce49143/research.0623.fig.001.jpg

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