Drug Discovery Pipeline, Hefei Institute of Stem Cell and Regenerative Medicine, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark.
Mater Sci Eng C Mater Biol Appl. 2020 Jan;106:110302. doi: 10.1016/j.msec.2019.110302. Epub 2019 Oct 12.
Nanotherapeutics and nanopharmaceuticals could achieve and facilitate earlier and more precise individual diagnosis, improve targeted therapies, reduce side effects, and enhance therapeutic monitoring. These advantages will improve quality of life, support a healthier and more independent aging population, and be instrumental in maximizing the cost-effectiveness of health care. However, the field of nanomedicine is at its early stage, most of the research still stays in the laboratory phase, and few success stories are translated into clinical trials and medical practice. This review will demonstrate the numerous challenges that are encountered during the development of commercial nanoparticle-based therapeutics and the possible solutions.
纳米治疗学和纳米药物学可以实现并促进更早、更精确的个体化诊断，改善靶向治疗，减少副作用，并加强治疗监测。这些优势将提高生活质量，支持更健康、更独立的老龄化人口，并有助于最大限度地提高医疗保健的成本效益。然而，纳米医学领域仍处于早期阶段，大多数研究仍停留在实验室阶段，只有少数成功案例转化为临床试验和医疗实践。本综述将展示在开发基于纳米颗粒的治疗方法时遇到的许多挑战，以及可能的解决方案。
