人胎儿肝脏对芳香胺的代谢及致突变性
Metabolism and mutagenicity of aromatic amines by human fetal liver.
作者信息
Aune T, Haugen A, Dybing E
出版信息
Arch Toxicol. 1985 Jun;57(2):136-8. doi: 10.1007/BF00343124.
PMID:4026573
Abstract
Human fetal liver microsomes were found to metabolize the carcinogen 2-acetylaminoflurene (AAF), the major metabolite being the deacetylated product 2-aminofluorene (AF). On the other hand, N-hydroxy-2-acetylaminofluorene (N-OH-AAF), a proximate carcinogenic metabolite, could not be detected. The human fetal liver samples converted AF and N-OH-AAF, but not AAF, to products mutagenic for S. typhimurium TA 98.
摘要
研究发现，人胎儿肝脏微粒体能够代谢致癌物2-乙酰氨基芴（AAF），主要代谢产物为脱乙酰化产物2-氨基芴（AF）。另一方面，未检测到近似致癌代谢物N-羟基-2-乙酰氨基芴（N-OH-AAF）。人胎儿肝脏样本可将AF和N-OH-AAF（而非AAF）转化为对鼠伤寒沙门氏菌TA 98具有致突变性的产物。
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