Mohr U, Reznik-Schüller H, Reznik G, Hilfrich J
J Natl Cancer Inst. 1975 Sep;55(3):681-3. doi: 10.1093/jnci/55.3.681.
Female Syrian hamsters were given a single sc dose of 45 mg diethylnitrosamine (DEN)/kg body weight on 1 of the 15 days of pregnancy. In the offspring of females treated on 1 of the first 11 days of pregnancy, no respiratory tract tumors were found. The offspring of mothers given DEN on 1 of the last 4 days (12-15) of pregnancy developed respiratory tract neoplasms at a rate of up to 95%. A lower incidence of tumors in other organs seemed independent of the day of DEN treatment.
在怀孕的15天中的某一天，给雌性叙利亚仓鼠单次皮下注射45毫克/千克体重的二乙基亚硝胺（DEN）。在怀孕前11天中某一天接受治疗的雌性仓鼠的后代中，未发现呼吸道肿瘤。在怀孕最后4天（第12 - 15天）中某一天给予DEN的母鼠后代，呼吸道肿瘤的发生率高达95%。其他器官肿瘤的较低发生率似乎与给予DEN的日期无关。
