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[早发性结直肠癌:我们应该何时开始筛查?]

[Early-onset colorectal cancer : When should we start with screening?].

作者信息

Hoffmeister Michael, Brenner Hermann

机构信息

Abteilung Klinische Epidemiologie und Alternsforschung, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Deutschland.

出版信息

Radiologie (Heidelb). 2025 Jun;65(6):405-409. doi: 10.1007/s00117-025-01453-x.

Abstract

BACKGROUND

In recent years, the number of new cases of colorectal cancer in people under the age of 50 (early-onset colorectal cancer, EOCRC) has increased, and extension of colorectal cancer screening for younger age groups is currently being discussed.

OBJECTIVES

To discuss whether the age for population-wide colorectal cancer screening should be lowered?

RESULTS

Extension of population-wide screening to younger age groups particularly to those under the age of 40 would be highly inefficient due to the low colorectal cancer incidence. Still, it could be considered for people at increased risk, including young adults with familial risk. Implementation of primary prevention measures would already be possible.

CONCLUSIONS

More targeted risk-adapted prevention and screening strategies are needed to reverse the rising trend of EOCRC and to detect colorectal cancer more frequently at an early stage.

摘要

背景

近年来,50岁以下人群的结直肠癌新发病例数(早发性结直肠癌,EOCRC)有所增加,目前正在讨论将结直肠癌筛查扩大到更年轻年龄组的问题。

目的

讨论是否应降低全民结直肠癌筛查的年龄?

结果

由于结直肠癌发病率较低,将全民筛查扩大到更年轻年龄组,特别是40岁以下人群,效率会非常低。不过,对于风险增加的人群,包括有家族风险的年轻人,可以考虑进行筛查。一级预防措施已经可以实施。

结论

需要更有针对性的、适应风险的预防和筛查策略,以扭转EOCRC上升趋势,并更频繁地在早期检测到结直肠癌。

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