Videla L A, Fernandez V, Valenzuela A
Alcohol. 1985 May-Jun;2(3):457-62. doi: 10.1016/0741-8329(85)90115-6.
Data presented here indicate that iron exposure exacerbates the changes in the glutathione status of the liver cell and the lipid peroxidative response of the tissue induced by acute ethanol intoxication. In these conditions, additivity in lipid peroxidation was found to occur either when the process was estimated by hepatic malondialdehyde formation, as well as by measurements of the biliary malondialdehyde release in the anesthetized rat and by the antioxidant-sensitive respiration in the perfused rat liver, procedures which are non-invasive for the tissue.
此处呈现的数据表明，铁暴露会加剧急性乙醇中毒诱导的肝细胞谷胱甘肽状态变化以及组织的脂质过氧化反应。在这些情况下，当通过肝脏丙二醛形成、麻醉大鼠胆汁中丙二醛释放量的测定以及灌注大鼠肝脏中抗氧化剂敏感呼吸作用来评估脂质过氧化过程时，发现脂质过氧化存在相加性，这些方法对组织而言是非侵入性的。
