Spitzer T Q, Harris B A
South Med J. 1977 Jan;70(1):41-2. doi: 10.1097/00007611-197701000-00019.
Two dosage regimens of penicillin V were compared in 327 patients with mild to moderately severe streptococcal pharyngitis. Patients fulfilling study criteria were randomly assigned to a b.i.d. or a t.i.d. dosage schedule. Those in the b.i.d. group were given 500 mg twice daily; those in the t.i.d. group were given 250 mg three times daily. Duration of therapy was ten days for both groups. Cure was based on prompt symptomatic improvement, subsidence of clinical signs, and negative throat cultures for group A beta-hemolytic streptococci. Both dosage schedules yielded similar cure rates, indicating that with penicillin V, a b.i.d. regimen is as effective as a t.i.d. regimen in treating streptococcal pharyngitis.
在327例轻至中度严重链球菌性咽炎患者中比较了两种青霉素V给药方案。符合研究标准的患者被随机分配到每日两次或每日三次给药方案。每日两次组的患者每日两次给予500mg；每日三次组的患者每日三次给予250mg。两组的治疗疗程均为十天。治愈的标准是症状迅速改善、临床体征消退以及A组β溶血性链球菌咽拭子培养阴性。两种给药方案的治愈率相似，这表明对于青霉素V，每日两次给药方案在治疗链球菌性咽炎方面与每日三次给药方案同样有效。
