Chellam V G, Rushton D I
Br J Obstet Gynaecol. 1985 Aug;92(8):808-14. doi: 10.1111/j.1471-0528.1985.tb03050.x.
A retrospective histopathological study of the placental and non-placental membranes and umbilical cords of 200 live and stillborn babies weighing less than 2.5 kg is reported. The pathological studies were specifically concerned with the presence of infection as evidenced by a polymorphonuclear leucocytic infiltrate at these sites. Inflammatory lesions were demonstrated in 48.5% of specimens. The incidence of inflammatory lesions was highest in those with prolonged rupture of the membranes, and in the placentas of the smallest and least mature infants of a size appropriate to their gestational age. Puerperal pyrexia, neonatal sepsis and perinatal mortality were also more common in the infected group but none of the perinatal deaths was directly attributable to infection. The role of infection as a cause of premature rupture of the membranes, premature labour and subsequent perinatal outcome is still unclear though our data would suggest it is not unimportant.
据报道，对200例体重不足2.5千克的活产儿和死产儿的胎盘、非胎盘胎膜及脐带进行了回顾性组织病理学研究。病理研究特别关注这些部位多形核白细胞浸润所证实的感染情况。48.5%的标本显示有炎性病变。炎性病变的发生率在胎膜长时间破裂的病例中最高，在与胎龄相符的最小且最不成熟婴儿的胎盘中也最高。感染组产褥热、新生儿败血症和围产期死亡率也更常见，但围产期死亡均非直接由感染所致。尽管我们的数据表明感染并非不重要，但感染作为胎膜早破、早产及随后围产期结局的原因，其作用仍不明确。
