Chuah M I, Farbman A I, Menco B P
Brain Res. 1985 Jul 15;338(2):259-66. doi: 10.1016/0006-8993(85)90155-6.
The maturation of olfactory receptor cells is facilitated by the presence of their target tissue, the olfactory bulb. Organ cultures of embryonic rat olfactory mucosa (OM) maintained in the presence of the presumptive olfactory bulb (POB) had a significantly higher (1.6 X) density of ciliated dendritic knobs than those without the POB. No significant difference was found in the density of non-ciliated dendritic knobs and total knob density in these two groups of cultures. A control group of explants in which the OM and POB had been separated and recombined also showed an increased ciliated dendritic knob density. The area of the olfactory epithelium was the same whether or not the POB was present. In addition, scanning electron microscopy observations revealed a high degree of heterogeneity in the surface morphology of the olfactory epithelium.
嗅球作为嗅觉受体细胞的靶组织，其存在促进了嗅觉受体细胞的成熟。在假定的嗅球（POB）存在的情况下维持的胚胎大鼠嗅黏膜（OM）器官培养物中，有纤毛的树突状小体密度显著更高（1.6倍），高于没有POB的培养物。在这两组培养物中，无纤毛的树突状小体密度和总小体密度没有显著差异。嗅黏膜和POB已分离并重新组合的外植体对照组也显示有纤毛的树突状小体密度增加。无论是否存在POB，嗅觉上皮的面积相同。此外，扫描电子显微镜观察显示嗅觉上皮的表面形态存在高度异质性。
