溃疡性结肠炎病程中诊断出的无症状威尔逊病：一例报告及文献复习
Asymptomatic Wilson's Disease Diagnosed during the Course of Ulcerative Colitis: A Case Report and Review.
作者信息
Kinjo Megumi, Sagami Shintaro, Nogami Akira, Serizawa Kanade, Shibui Shunsuke, Umeda Satoko, Asonuma Kunio, Saito Hidetsugu, Nakano Masaru, Hibi Toshifumi, Kobayashi Taku
机构信息
Department of Gastroenterology, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
出版信息
Inflamm Intest Dis. 2025 Mar 13;10(1):85-89. doi: 10.1159/000545142. eCollection 2025 Jan-Dec.
INTRODUCTION
While previous reports have suggested an association between Wilson's disease (WD) and ulcerative colitis (UC), we present the first case of asymptomatic WD diagnosed during the treatment course of UC.
CASE PRESENTATION
A 14-year-old male receiving treatment for UC developed elevated liver enzymes without any related symptoms. After ruling out drug-induced liver toxicity and other possible causes of hepatitis, further investigation was initiated due to his sister's subsequent diagnosis of WD. Tests revealed low serum ceruloplasmin and ATP7B gene variants, confirming WD. Following zinc therapy, liver enzymes have been normalized, and his previously refractory UC became under control.
CONCLUSION
This case raises important questions about potential pathophysiological interactions between the two diseases.
引言
虽然先前的报告表明威尔逊病（WD）与溃疡性结肠炎（UC）之间存在关联，但我们报告了首例在UC治疗过程中诊断出的无症状WD病例。
病例介绍
一名接受UC治疗的14岁男性出现肝酶升高，但无任何相关症状。在排除药物性肝毒性和其他可能的肝炎病因后，由于其妹妹随后被诊断为WD，遂展开进一步调查。检查发现血清铜蓝蛋白水平低和ATP7B基因变异，确诊为WD。锌治疗后，肝酶恢复正常，其先前难治的UC也得到了控制。
结论
该病例引发了关于这两种疾病潜在病理生理相互作用的重要问题。
Zotero 插件