Hardy S G
Brain Res. 1985 Jul 29;339(2):281-4. doi: 10.1016/0006-8993(85)90093-9.
Bipolar stimulating electrodes were placed into the medial prefrontal cortex (PFC) or control sites (occipital or cerebellar cortices) in adult male rats. Subsequently, it was determined that PFC stimulation resulted in a significant elevation of nociceptive response latencies, as tested using hot plate and tail flick techniques. Stimulation in control sites did not produce an increase in these response latencies. Rats receiving PFC stimulation were able to respond normally to various innocuous stimuli. Furthermore, seizures were not observed in these rats. These facts indicated that PFC stimulation did not disorient the animals nor inhibit their voluntary motor activity. The results of this study seem to indicate that the PFC is a site from which stimulus-produced analgesia may be elicited.
将双极刺激电极植入成年雄性大鼠的内侧前额叶皮质（PFC）或对照部位（枕叶或小脑皮质）。随后，通过热板法和甩尾法测试发现，刺激PFC会导致伤害性反应潜伏期显著延长。刺激对照部位并不会使这些反应潜伏期增加。接受PFC刺激的大鼠能够对各种无害刺激正常做出反应。此外，在这些大鼠中未观察到癫痫发作。这些事实表明，刺激PFC不会使动物迷失方向，也不会抑制其自主运动活动。本研究结果似乎表明，PFC是一个可以引发刺激产生镇痛作用的部位。
