Morgan Michael J, Franklin Keith B J
Department of Psychology, McGill University, Montreal, Que. H3A 1B1 Canada.
Pain. 1988 Apr;33(1):109-121. doi: 10.1016/0304-3959(88)90210-2.
Electrical stimulation of dorsal and dorsolateral periaqueductal gray (PAG) and internal capsule (IC) sites in the rat elicited tail flick and formalin test stimulation-produced analgesia (SPA). SPA from PAG sites was associated with aversion. SPA from IC sites was associated with aversion, generalized seizures and catalepsy. Ventrobasal nucleus of thalamus (VB) stimulation did not elicit analgesia or aversion but did induce behavior characteristic of limbic seizures. A sub-anesthetic dose of sodium pentobarbital (20 mg/kg) suppressed IC stimulation-produced generalized seizures and catalepsy, and attenuated, but did not eliminate, tail flick test analgesia. These data suggest that SPA from IC sites in the rat is partially confounded with reduced responsivity. The hypothesis that SPA associated with aversion may represent a form of stress-induced analgesia is discussed.
对大鼠中脑导水管周围灰质背侧和背外侧（PAG）以及内囊（IC）部位进行电刺激，可引发甩尾反应和福尔马林试验刺激产生的镇痛作用（SPA）。来自PAG部位的SPA与厌恶反应相关。来自IC部位的SPA与厌恶反应、全身性癫痫发作和僵住症相关。刺激丘脑腹侧基底核（VB）未引发镇痛或厌恶反应，但确实诱发了边缘性癫痫发作的行为特征。亚麻醉剂量的戊巴比妥钠（20mg/kg）可抑制IC刺激产生的全身性癫痫发作和僵住症，并减弱但并未消除甩尾试验中的镇痛作用。这些数据表明，大鼠IC部位的SPA部分与反应性降低混淆。文中讨论了与厌恶反应相关的SPA可能代表一种应激诱导镇痛形式的假说。
