Bhat Ashok, Desai Rohan, Vankalakunti Mahesha
Department of Nephrology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.
Department of Pathology, Manipal Hospitals, Bangalore, India.
Case Rep Nephrol Dial. 2025 Mar 21;15(1):60-69. doi: 10.1159/000545186. eCollection 2025 Jan-Dec.
Herbal medications have been utilized for centuries to treat various ailments, yet their potential to induce renal damage is often underestimated. The popularity of herbal remedies, especially in rural India, stems from cultural beliefs in their holistic healing properties.
This case series comprises 4 patients exhibiting varied renal presentations linked to herbal medication usage. Notably, oxalate nephropathy emerged as a predominant finding. Through comprehensive clinical assessments and renal biopsies, we elucidated the pathophysiological mechanisms underlying herbal nephrotoxicity. Timely recognition and discontinuation of the offending herb, alongside tailored therapeutic interventions like corticosteroid administration, facilitated favourable patient outcomes.
These cases underscore the importance of considering herbal remedies as potential culprits in renal dysfunction, particularly in regions where their usage is prevalent. Our findings emphasize the imperative for healthcare practitioners to proactively inquire about herbal medication use in patients with renal failure. Heightened awareness and further research into the safety and mechanisms of herbal nephrotoxicity are essential for optimizing patient care and preventing herb-induced kidney injury.
草药已被使用了几个世纪来治疗各种疾病,但其诱发肾损伤的可能性常常被低估。草药疗法的流行,尤其是在印度农村地区,源于人们认为其具有整体治疗功效的文化观念。
本病例系列包括4例与草药使用相关的表现各异的肾脏病例。值得注意的是,草酸盐肾病是主要发现。通过全面的临床评估和肾活检,我们阐明了草药肾毒性的病理生理机制。及时识别并停用致病草药,同时进行如使用皮质类固醇等针对性的治疗干预,促进了患者的良好预后。
这些病例强调了将草药疗法视为肾功能障碍潜在病因的重要性,特别是在草药使用普遍的地区。我们的研究结果强调,医护人员必须主动询问肾衰竭患者的草药使用情况。提高对草药肾毒性安全性和机制的认识并进行进一步研究,对于优化患者护理和预防草药引起的肾损伤至关重要。