Tunstad Paula Aarseth, Kvam Tor-Morten, Uthaug Malin V, Stewart Lowan H, Andersen Kristoffer A A, Grønnerød Cato
Indre Sogn Regional Psychiatric Clinic, Førde, Norway.
Faculty of Medicine, University of Oslo, Oslo, Norway.
Front Pharmacol. 2025 Apr 10;16:1556299. doi: 10.3389/fphar.2025.1556299. eCollection 2025.
Interest in the therapeutic effects of classical psychedelics has risen recently. However, little epidemiological knowledge exists about the use of classical psychedelics in Scandinavian countries. Additionally, there is a limited understanding of what factors drive self-reported improvement in wellbeing. The aim of this study was to investigate the relationship between the use of classical psychedelics and outcomes related to subjective wellbeing in an adult, Norwegian-speaking sample. We examined how contextual and phenomenological variables were associated with self-reported subjective wellbeing.
Using an anonymous internet survey, we recruited Norwegian speaking subjects who have had a memorable experience after taking a classic psychedelic substance. Data are presented by using descriptive statistics about the sample and two hierarchical regression analyses. The first regression analysis examined contextual variables, and the second examined variables related to acute phenomena during the experience.
The survey showed that 85% of the sample reported a small to large positive change in subjective wellbeing after their experience with classical psychedelics. Integration, ego dissolution, and emotional breakthrough had a clear, positive predictive effect on the participants' self-reported subjective wellbeing. Variables with lower but significant effects were the degree of challenging experiences, settings associated with nature or ceremony, and a therapeutic or seeking intention.
The use of classical psychedelics leads to an increase in subjective wellbeing for the majority of the participants. This relationship seems dependent upon various experiential aspects of acute subjective drug effects. These findings should be viewed as hypothesis-generating rather than confirmatory due to the study's limitations.
近期,人们对经典迷幻剂的治疗效果兴趣大增。然而,关于斯堪的纳维亚国家使用经典迷幻剂的流行病学知识却知之甚少。此外,对于哪些因素促使幸福感自我报告有所改善,人们的了解也很有限。本研究旨在调查在一个讲挪威语的成年样本中,经典迷幻剂的使用与主观幸福感相关结果之间的关系。我们研究了背景和现象学变量如何与自我报告的主观幸福感相关联。
我们通过一项匿名网络调查,招募了在服用经典迷幻物质后有过难忘经历的讲挪威语的受试者。数据通过样本的描述性统计以及两次层次回归分析呈现。第一次回归分析考察背景变量,第二次考察与体验过程中急性现象相关的变量。
调查显示,85%的样本报告称,在体验经典迷幻剂后,主观幸福感有了小到较大程度的积极变化。整合、自我消解和情感突破对参与者自我报告的主观幸福感有明显的积极预测作用。影响较小但显著的变量包括挑战性体验的程度、与自然或仪式相关的环境,以及治疗或探索意图。
使用经典迷幻剂会使大多数参与者的主观幸福感增强。这种关系似乎取决于急性主观药物效应的各种体验方面。由于本研究存在局限性,这些发现应被视为产生假设而非确定性结论。