Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Nathan Shock Drive, Baltimore, Maryland, United States of America.
Department of Neuroscience, Johns Hopkins University School of Medicine, Nathan Shock Drive, Baltimore, Maryland, United States of America.
PLoS One. 2019 Apr 23;14(4):e0214377. doi: 10.1371/journal.pone.0214377. eCollection 2019.
Naturally occurring and psychedelic drug-occasioned experiences interpreted as personal encounters with God are well described but have not been systematically compared. In this study, five groups of individuals participated in an online survey with detailed questions characterizing the subjective phenomena, interpretation, and persisting changes attributed to their single most memorable God encounter experience (n = 809 Non-Drug, 1184 psilocybin, 1251 lysergic acid diethylamide (LSD), 435 ayahuasca, and 606 N,N-dimethyltryptamine (DMT)). Analyses of differences in experiences were adjusted statistically for demographic differences between groups. The Non-Drug Group was most likely to choose "God" as the best descriptor of that which was encountered while the psychedelic groups were most likely to choose "Ultimate Reality." Although there were some other differences between non-drug and the combined psychedelic group, as well as between the four psychedelic groups, the similarities among these groups were most striking. Most participants reported vivid memories of the encounter experience, which frequently involved communication with something having the attributes of being conscious, benevolent, intelligent, sacred, eternal, and all-knowing. The encounter experience fulfilled a priori criteria for being a complete mystical experience in approximately half of the participants. More than two-thirds of those who identified as atheist before the experience no longer identified as atheist afterwards. These experiences were rated as among the most personally meaningful and spiritually significant lifetime experiences, with moderate to strong persisting positive changes in life satisfaction, purpose, and meaning attributed to these experiences. Among the four groups of psychedelic users, the psilocybin and LSD groups were most similar and the ayahuasca group tended to have the highest rates of endorsing positive features and enduring consequences of the experience. Future exploration of predisposing factors and phenomenological and neural correlates of such experiences may provide new insights into religious and spiritual beliefs that have been integral to shaping human culture since time immemorial.
自然发生和迷幻药物引起的体验被描述为与上帝的个人相遇,但尚未进行系统比较。在这项研究中,五组参与者参与了一项在线调查,其中包含详细的问题,这些问题描述了他们最难忘的上帝相遇体验的主观现象、解释和持久变化(n=809 例非药物组、1184 例裸盖菇素组、1251 例麦角酸二乙酰胺(LSD)组、435 例瓜拉那组和 606 例 N,N-二甲基色胺(DMT)组)。对经验差异的分析在统计学上根据组间的人口统计学差异进行了调整。非药物组最有可能选择“上帝”作为所遇到的最佳描述,而迷幻组最有可能选择“终极现实”。虽然非药物组与联合迷幻组以及四种迷幻组之间存在一些其他差异,但这些组之间的相似之处最为引人注目。大多数参与者报告说对相遇体验有生动的记忆,这些体验经常涉及与具有意识、仁慈、智慧、神圣、永恒和全知等属性的事物进行交流。在大约一半的参与者中,相遇体验符合先验的完整神秘体验标准。在体验之前自认为是无神论者的人中,超过三分之二的人在体验后不再认为自己是无神论者。这些体验被评为一生中最有意义和最具精神意义的体验之一,与这些体验相关的生活满意度、目标和意义的中度至强烈持久积极变化。在四种迷幻药物使用者中,裸盖菇素和 LSD 组最为相似,而瓜拉那组则倾向于更高的比例认可体验的积极特征和持久后果。对这种体验的易发性因素和现象学及神经相关性的进一步探索,可能为宗教和精神信仰提供新的见解,这些信仰自古以来一直是塑造人类文化的重要组成部分。