Alamillo-Vásquez Jorge Augusto, Pérez-Torres Claudia-Anahí, Ibarra-Laclette Enrique, Ramón-Farías Feliza, Nicasio-Torres Pilar, Alatorre-Cobos Fulgencio
Red de Estudios Moleculares Avanzados (REMAV), Instituto de Ecología, A.C. (INECOL), Carretera Antigua a Coatepec 351, Col. El Haya, Xalapa 91073, Veracruz, Mexico.
SECIHTI-Red de Estudios Moleculares Avanzados (REMAV), Instituto de Ecología, A.C. (INECOL), Carretera Antigua a Coatepec 351, Col. El Haya, Xalapa 91073, Veracruz, Mexico.
Metabolites. 2025 Mar 23;15(4):216. doi: 10.3390/metabo15040216.
Plant-based traditional medicine integrates beliefs, knowledge, and practices to prevent and treat multiple diseases. is a large and worldwide-spread genus belonging to Euphorbiaceae, a family well known for comprising many species with medicinal properties due to its high diversity of phytochemical constituents with biological activities. Among the various benefits of species in traditional medicine, its use in cancer treatment has recently received significant attention from the scientific community. This review provides a general overview of different studies on the genus in the research for alternative cancer treatments and the impact of its secondary metabolite catalog on cell cycle targets. Our analysis indicates that just under 30 secondary metabolites have been identified so far in latex and extracts obtained from leaves, twigs, or bark from 22 different species. Based on standard assays using cell lines or human platelets, these molecules show multiple biological activities mainly compromising cell viability and cell cycle progression, supporting the ethnobotanical use of species for cancer treatment. Several studies indicate that metabolites target CDK-cyclin complexes and signaling routes that trigger apoptosis; however, further studies are needed to better understand the molecular mechanisms underlying metabolites' effects and their accurate future applications in cancer treatment.
植物源传统医学融合了信仰、知识和实践，用于预防和治疗多种疾病。[此处缺失植物名]是大戟科一个分布广泛的大属，该科以包含许多具有药用特性的物种而闻名，因为其具有生物活性的植物化学成分高度多样。在传统医学中，[此处缺失植物名]物种的各种益处中，其在癌症治疗中的应用最近受到了科学界的极大关注。本综述概述了关于[此处缺失植物名]属在替代癌症治疗研究中的不同研究，以及其次生代谢产物目录对细胞周期靶点的影响。我们的分析表明，到目前为止，在从22种不同的[此处缺失植物名]物种的乳胶以及叶、枝或树皮提取物中仅鉴定出了不到30种次生代谢产物。基于使用细胞系或人类血小板的标准检测，这些分子显示出多种生物活性，主要影响细胞活力和细胞周期进程，支持了[此处缺失植物名]物种在癌症治疗中的民族植物学应用。几项研究表明，[此处缺失植物名]代谢产物靶向CDK - 细胞周期蛋白复合物以及触发细胞凋亡的信号通路；然而，需要进一步研究以更好地理解[此处缺失植物名]代谢产物作用的分子机制及其在癌症治疗中的准确未来应用。
