Stragier Séverine, Duchateau Jacques, Cotton Frédéric, Smet Julie, Wolff Fleur, Tresnie Jérémy, Carpentier Alain
Research Unit in Cardio-Respiratory Physiology, Exercise & Nutrition, Faculty of Human Movement Sciences, Université libre de Bruxelles, 1070 Brussels, Belgium.
Laboratory of Applied Biology and Neurophysiology, Faculty of Human Movement Sciences, Université libre de Bruxelles, 1070 Brussels, Belgium.
Sports (Basel). 2025 Apr 9;13(4):111. doi: 10.3390/sports13040111.
To assess the impact of metabolic stress on blood lactate, muscle damage, inflammatory and hormonal responses following a high-load (70% maximum) strength training session, we compared two methods with a similar number of repetitions but that differed by their metabolic demand: the 3/7 method consisting in two series of five sets of an increasing number of repetitions (3 to 7) with a short inter-set interval (15 s) and the 8 × 6 method that comprises eight sets of six repetitions with a longer inter-set interval (2.5 min). Blood concentrations in lactate, creatine kinase (CK), myoglobin (MB), interleukine-6 (IL-6), leukocytes, growth hormone (GH), insulin-like growth factor-1 (IGF-1) and cortisol were determined before and after each session. Lactate concentration increased more (11.9 vs. 3.1 mmol/L; < 0.001) for the 3/7 method whereas CK and MB concentrations were augmented similarly ( > 0.05) for both methods. Inflammatory markers (leukocytes and IL-6) increased ( < 0.01) more after the 3/7 method. GH and cortisol concentrations also increased more ( < 0.001) after the 3/7 method with no difference in IGF-1 concentrations between methods. Positive associations were found between the change in lactate and changes in IL-6 (r = 0.47; < 0.01), GH (r = 0.58; < 0.001) and cortisol (r = 0.61; < 0.001) concentrations. In conclusion, the greater lactate accumulation induced by short inter-set intervals during a high-load training session is associated with enhanced inflammatory and hormonal responses, suggesting that metabolic stress might contribute to the greater adaptative response previously observed with this method.
为了评估高负荷（最大负荷的70%）力量训练后代谢应激对血乳酸、肌肉损伤、炎症和激素反应的影响，我们比较了两种重复次数相似但代谢需求不同的方法：3/7方法，即两组，每组五组，重复次数递增（3至7次），组间休息间隔短（15秒）；8×6方法，即八组，每组六次重复，组间休息间隔长（2.5分钟）。在每次训练前后测定血乳酸、肌酸激酶（CK）、肌红蛋白（MB）、白细胞介素-6（IL-6）、白细胞、生长激素（GH）、胰岛素样生长因子-1（IGF-1）和皮质醇的浓度。3/7方法的乳酸浓度升高更多（11.9对3.1 mmol/L；<0.001），而两种方法的CK和MB浓度升高相似（>0.05）。3/7方法后炎症标志物（白细胞和IL-6）升高更多（<0.01）。3/7方法后GH和皮质醇浓度也升高更多（<0.001），两种方法之间IGF-1浓度无差异。乳酸变化与IL-6（r = 0.47；<0.01）、GH（r = 0.58；<0.001）和皮质醇（r = 0.61；<0.001）浓度变化之间存在正相关。总之，高负荷训练期间短组间休息间隔诱导的更大乳酸积累与增强的炎症和激素反应相关，表明代谢应激可能有助于此前用该方法观察到的更大适应性反应。
