Narita T, Kudo H
Cancer Res. 1985 Sep;45(9):4175-7.
The effect of melatonin on the growth of B16 mice melanoma was examined. Male and female BALB/c athymic mice, inoculated with 7 X 10(4) melanoma cells, were given drinking water containing melatonin (5 micrograms/g body weight/day) and 0.5% ethanol. Compared to control animals the melatonin treated male and female athymic mice had significantly smaller tumors on Day 40. The weights of the testes, the ovaries, and the adrenal glands of melatonin treated mice were significantly reduced compared to control animals. These data indicate that melatonin p.o. significantly inhibited the growth of B16 mouse melanoma and that the antitumor effect of melatonin was associated with a significant decrease in gonadal and adrenal weights.
研究了褪黑素对B16小鼠黑色素瘤生长的影响。将接种了7×10⁴个黑色素瘤细胞的雄性和雌性BALB/c无胸腺小鼠，给予含褪黑素（5微克/克体重/天）和0.5%乙醇的饮用水。与对照动物相比，经褪黑素处理的雄性和雌性无胸腺小鼠在第40天时肿瘤明显更小。与对照动物相比，经褪黑素处理的小鼠的睾丸、卵巢和肾上腺重量显著降低。这些数据表明，口服褪黑素可显著抑制B16小鼠黑色素瘤的生长，且褪黑素的抗肿瘤作用与性腺和肾上腺重量的显著降低有关。
