Herman Jessica L, Lidbury Jonathan A, Atiee Genna F, Washburn Shannon E, Patterson Carly A
Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX.
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX.
Am J Vet Res. 2025 Apr 25;86(8). doi: 10.2460/ajvr.25.02.0055. Print 2025 Aug 1.
To evaluate the performance of a second-generation flash glucose monitoring system (FGMS; FreeStyle Libre 2) in nondiabetic dogs during rapidly induced hypoglycemia.
In a prospective, observational study, regular insulin was administered to 23 healthy dogs to induce hypoglycemia, with subsequent correction. Serial measurements of interstitial glucose with FGMS and blood glucose (BG) with a portable BG monitor (PBGM) were recorded every 10 minutes for 90 minutes. At each time point, blood was also collected for gold standard BG measurement via clinical chemistry analyzer. Analytical and clinical accuracy was determined by fulfillment of International Organization for Standardization 15197:2013 criteria.
For BG values < 100 mg/dL, 67.2% of PBGM measurements and 50.9% of FGMS measurements were within ± 15 mg/dL of the reference method. In Parkes error grid analysis, 94.9% of PBGM and 88.6% of FGMS measurements fell within zones A and B. Readings within higher-risk zones were rare, with no PBGM values and 0.6% of FGMS values in zone D and neither producing readings in zone E.
In this model of rapidly induced hypoglycemia, the FGMS demonstrated limited analytical accuracy compared to the reference standard. However, it rarely produced glucose readings likely to lead to detrimental clinical decisions.
The FreeStyle Libre 2 is clinically useful for monitoring glucose trends in dogs, though results should be interpreted with caution during periods of rapid glycemic change.
评估第二代闪光葡萄糖监测系统（FGMS；FreeStyle Libre 2）在非糖尿病犬快速诱导低血糖期间的性能。
在一项前瞻性观察研究中，对23只健康犬给予常规胰岛素以诱导低血糖，随后进行纠正。使用FGMS每隔10分钟连续测量组织间液葡萄糖90分钟，并使用便携式血糖仪（PBGM）测量血糖（BG）。在每个时间点，还采集血液通过临床化学分析仪进行金标准BG测量。通过符合国际标准化组织15197:2013标准来确定分析准确性和临床准确性。
对于BG值<100 mg/dL，PBGM测量值的67.2%和FGMS测量值的50.9%在参考方法的±15 mg/dL范围内。在帕克斯误差网格分析中，PBGM测量值的94.9%和FGMS测量值的88.6%落在A区和B区。高风险区内的读数很少，D区没有PBGM值，FGMS值的0.6%在D区，且两者在E区均未产生读数。
在这种快速诱导低血糖的模型中，与参考标准相比，FGMS的分析准确性有限。然而，它很少产生可能导致有害临床决策的葡萄糖读数。
FreeStyle Libre 2在临床上可用于监测犬的血糖趋势，尽管在血糖快速变化期间应谨慎解释结果。
