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蛋白质 - 热量营养不良治疗期间的血容量变化。

Blood volume changes during treatment of protein-calorie malnutrition.

作者信息

Viart P

出版信息

Am J Clin Nutr. 1977 Mar;30(3):349-54. doi: 10.1093/ajcn/30.3.349.

DOI:10.1093/ajcn/30.3.349
PMID:402807
Abstract

Intravascular volmes were sequentially determined in 13 African children recovering from protein-calorie malnutrition. The red cell volume was measured by a radiochromium technique; the total blood volume and the plasma volume were calculated. The absolute volumes were related to body size and were compared with the control values. Before treatment, the total blood volume was low per unit of body size, the red cell volume was more reduced than the plasma volume. On the 20th realimentation day, the absolute red cell volume had increased less than the absolute plasma volume, the total blood volume was almost normal per unti of body size. On the 60th realimentation day, near recovery, the absolute red cell volume had again increased, but again less than the absolute plasma volume, and the venous hematocrit was lower than on admission; the total blood volume was normalized per unit of body size, the red cell volume was low with a supranormal plasma volume. The rehabilitation period was characterized by an aggravation of the hemodilution already present before treatment. The significance of the changes in volemia per unit of body size was unclear because of the changing body composition.

摘要

对13名从蛋白质-热量营养不良中恢复的非洲儿童依次测定血管内容量。采用放射性铬技术测量红细胞容量;计算全血容量和血浆容量。绝对容量与身体大小相关,并与对照值进行比较。治疗前,每单位身体大小的全血容量较低,红细胞容量比血浆容量减少得更多。在再喂养第20天时,绝对红细胞容量的增加小于绝对血浆容量的增加,每单位身体大小的全血容量几乎正常。在再喂养第60天时,接近恢复时,绝对红细胞容量再次增加,但再次小于绝对血浆容量,静脉血细胞比容低于入院时;每单位身体大小的全血容量恢复正常,红细胞容量低而血浆容量超常。康复期的特点是治疗前就已存在的血液稀释加重。由于身体组成的变化,每单位身体大小的血容量变化的意义尚不清楚。

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