A Novel Approach to Predict the Location and Fatigue Life of Intervertebral Disc Degeneration.

This study presents a novel approach for predicting the location and fatigue life of degenerative intervertebral discs (IVDs) under cyclic loading conditions, aiming to improve the understanding of disc degeneration mechanisms. Based on mechanical theories linking IVD degeneration to stress imbalance and water loss, a finite element (FE) model of the L4-L5 lumbar spine was developed, combining probability-weighted anatomical structures, inverse dynamics, and cumulative fatigue mechanics. By quantifying stress variations and calculating cumulative damage across disc regions, stress-concentration areas prone to degeneration were identified, and validation via a case study of a retired weightlifter diagnosed with intervertebral disc disease (IVDD) demonstrated that the predicted degeneration location correlated well with affected areas observed in CT scan images. These findings suggest that prolonged, abnormal stress imbalances within the disc may contribute significantly to degeneration, offering potential clinical applications in preventive assessment and targeted treatment for spine health.