信使核糖核酸作为治疗性分子的光明未来。
The Bright Future of mRNA as a Therapeutic Molecule.
作者信息
Vélez Dora Emma, Torres Blanca Licia, Hernández Greco
机构信息
mRNA and Cancer Laboratory, Unit of Biomedical Research on Cancer, Instituo Nacional de Cancerología (National Institute of Cancer, INCan), Mexico City 14080, Mexico.
Escuela de Medicina y Ciencias de la Salud, Tecnológico de Monterrey, Mexico City 14380, Mexico.
出版信息
Genes (Basel). 2025 Mar 26;16(4):376. doi: 10.3390/genes16040376.
The rapid success of messenger (m) RNA vaccines against COVID-19 has pushed the mRNA to the forefront of drug research. The promise of mRNA-based therapeutics and vaccines in other areas is not new but is now emerging stronger. We review basic concepts, key historical aspects, and recent research on mRNA as a therapeutic molecule to fight infectious diseases and cancer. We also show a current patent perspective of this field. Altogether, we describe that the technology of mRNA as a therapeutic molecule is a rapidly moving field aiming for a bright future.
针对新型冠状病毒肺炎的信使核糖核酸（mRNA）疫苗迅速取得成功，使mRNA在药物研究领域处于前沿地位。基于mRNA的疗法和疫苗在其他领域的前景并非新鲜事，但如今正展现出更强大的影响力。我们回顾了mRNA作为治疗分子用于对抗传染病和癌症的基本概念、关键历史方面以及近期研究。我们还展示了该领域目前的专利情况。总体而言，我们描述了mRNA作为治疗分子的技术是一个快速发展的领域，前景光明。
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