Diaconu Stefania, Ciopleias Bianca, Zarnoveanu Anca, Falup-Pecurariu Cristian
Department of Neurology, County Clinic Hospital, 500326 Brasov, Romania.
Faculty of Medicine, Transilvania University, 500019 Brasov, Romania.
Medicina (Kaunas). 2025 Mar 26;61(4):591. doi: 10.3390/medicina61040591.
: Sleep and pain are non-motor symptoms encountered frequently in Parkinson's disease (PD). Several subtypes of pain have been identified in PD, with different associations with other non-motor symptoms. To evaluate the prevalence of various subtypes of pain in a PD cohort and their associations with sleep disturbances and quality of sleep. : In this study, 131 consecutive PD patients were assessed, focusing on pain and sleep using several validated scales and questionnaires. : According to KPPQ, the most reported types of pain were musculoskeletal pain (82.44%), nocturnal pain (58.77%), and radicular pain (55.72%). "Bad sleepers" (PSQI score > 5) reported significantly more pain than "good sleepers" regarding all KPPS subdomains, with statistically significant differences observed in the following domains: musculoskeletal pain (5.48 ± 3.50 vs. 2.70 ± 2.67, < 0.001), chronic pain, specifically central pain (1.19 ± 2.01 vs. 0.15 ± 0.71, = 0.004), nocturnal pain, specifically pain related to akinesia (2.26 ± 2.74 vs. 0.64 ± 1.22, = 0.001), and radicular pain (4.35 ± 4.20 vs. 2.45 ± 3.55, = 0.022). The prevalence of sleep disturbances was higher in patients with nocturnal pain (odds = 1.165, 95% CI: 1.064-1.276, = 0.001), orofacial pain (odds = 1.108, 95% CI: 1.051-1.167, < 0.001), and radicular pain (odds = 1.015, 95% CI: 1.015-1.149, = 0.015). : Pain is common in PD patients with sleep disorders. Identifying specific types of pain that are associated with sleep disorders and their correct management may improve sleep quality.
睡眠和疼痛是帕金森病(PD)中经常遇到的非运动症状。在PD中已确定了几种疼痛亚型,它们与其他非运动症状有不同的关联。评估PD队列中各种疼痛亚型的患病率及其与睡眠障碍和睡眠质量的关联。:在本研究中,对131例连续的PD患者进行了评估,使用几种经过验证的量表和问卷重点关注疼痛和睡眠。:根据KPPQ,报告最多的疼痛类型是肌肉骨骼疼痛(82.44%)、夜间疼痛(58.77%)和神经根性疼痛(55.72%)。“睡眠不佳者”(PSQI评分>5)在所有KPPS子领域报告的疼痛明显多于“睡眠良好者”,在以下领域观察到统计学显著差异:肌肉骨骼疼痛(5.48±3.50对2.70±2.67,<0.001)、慢性疼痛,特别是中枢性疼痛(1.19±2.01对0.15±0.71,=0.004)、夜间疼痛,特别是与运动不能相关的疼痛(2.26±2.74对0.64±1.22,=0.001)和神经根性疼痛(4.35±4.20对2.45±3.55,=0.022)。夜间疼痛(优势比=1.165,95%置信区间:1.064 - 1.276,=0.001)、口面部疼痛(优势比=1.108,95%置信区间:1.051 - 1.167,<0.001)和神经根性疼痛(优势比=1.015,95%置信区间:1.015 - 1.149,=0.015)患者的睡眠障碍患病率更高。:疼痛在患有睡眠障碍的PD患者中很常见。识别与睡眠障碍相关的特定疼痛类型及其正确管理可能会改善睡眠质量。